Treatment of Latent Autoimmune Diabetes of the Adult

Launched by NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY · Jun 8, 2010

Keywords

ClinConnect Summary

Latent autoimmune diabetes of the adult (LADA) is usually defined as a form of diabetes where the onset of diabetes takes place approximately after 30 years of age, where there is presence of beta-cell directed antibodies (mostly anti-GAD) and where there is no clinical need for insulin treatment during the first 6 months after the diagnosis of diabetes.

The aetiology and treatment of LADA patients is much less elucidated than is the case for type 1 diabetes (DM1) and type 2 diabetes (DM2). LADA constitutes about 10 % of the total diabetic population in many countries. LADA is therefore mo...

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Eligibility criteria

• Inclusion Criteria:
• • Diabetes diagnosed during 0-3 years before entering the study.
• • Age \> or equal to 30 years \< or equal to 75 years
• • anti-GAD positivity
• • fasting C-peptide \> or equal to 0,3 ng/ml
• • no need for insulin treatment by clinical judgement for at least 3 months following the diagnosis of diabetes.
• • HbA1c \> 15 % above the upper limit of normal
• Exclusion Criteria:
• • Renal insufficiency (plasma creatinine \> 150 mol/L)
• • Severe retinopathy (proliferative or pre-proliferative)
• • Severe cardiac disease (NYHA III-IV)
• • Chronic severe illness judged by the investigator
• • Females of reproductive age who wish to become pregnant during the study