Efficacy of Higher Albendazole and Ivermectin Doses on Wuchereria Bancrofti Microfilarial Clearance in Malawi
Launched by LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE · Oct 1, 2010
Trial Information
Current as of May 08, 2025
Terminated
Keywords
ClinConnect Summary
The proposed study will enrol up to 120 volunteers with microfilaremic Wuchereria bancrofti infection who would be randomized to receive standard annual treatment (albendazole 400 mg + ivermectin 200 mcg/kg), annual treatment with an increased dose of albendazole (albendazole 800 mg + ivermectin 200400 mcg/kg) or semi-annual treatment with a standard (albendazole 400 mg + ivermectin 200 mcg/kg), or an increased albendazole dose (albendazole 800 mg + ivermectin 200 400 mcg/kg). Microfilarial levels, as well as measures of adult worm burden (circulating antigen) will be followed every six mon...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • understand and sign informed consent
- • willing to undergo night blood sampling every 6 months for 2 years
- • Age 18 to 55 years
- • Haemoglobin of equal or above 9g/dl
- • Microfilarial level of equal or above 80mg/dl
- Exclusion Criteria:
- • Non- consenting
- • Pregnancy or lactation
- • Treatment with albendazole or ivermectin within the previous 6 months
- • Known allergy to the study drugs
About London School Of Hygiene And Tropical Medicine
The London School of Hygiene and Tropical Medicine (LSHTM) is a prestigious research institution renowned for its leadership in global health and infectious disease research. Committed to advancing public health through innovative research and education, LSHTM conducts a wide array of clinical trials aimed at improving health outcomes in diverse populations. With a multidisciplinary team of experts, LSHTM leverages cutting-edge methodologies and collaborative partnerships to address pressing health challenges, particularly in low- and middle-income countries. The institution's dedication to evidence-based solutions underscores its pivotal role in shaping health policies and practices worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Karonga, , Malawi
Patients applied
Trial Officials
Neil French, MB ChB PHD
Principal Investigator
London School of Hygiene and Tropical Medicine
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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