The Effect of Heparin in Treatment IVF-ET Failure

Launched by YAZD MEDICAL UNIVERSITY · Oct 1, 2010

Keywords

ClinConnect Summary

Introduction Embryo transfer failure is defined as ≥3 IVF-embryo transfer failures without pregnancy . In spite of transfer of 3 good quality embryos , just 20-30% of women undergoing IVF will achieve ongoing pregnancy . There are multiple factors that influence IVF-failure.

Autoantibodies may be one of the possible causes of IVF-failure , especially in unexplained and mechanical infertility .

In some studies , antiphospholipid antibody is considered as causative factor on implantation and embryo failure. However some investigators showed that combination therapy with heparin/aspirin in w...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients who were 19-35 years old
• • basal FSH \< 10 IU/l
• • body mass index ( BMI ) \< 29 Kg/m²
• • presence of both ovaries
• • three or more pervious IVF-ET failures
• • Top-quality embryos for transfer .
• Exclusion Criteria:
• • Women with polycystic ovary syndrome ( PCOS)
• • endometriosis
• • hydrosalpinx
• • chronic systemic disease( liver, renal , thyroid and thrombocytopenia ) ●Abnormal uterine cavity
• • sever male factor ( azospermia )
• • Patients who had contraindication for unfractionated heparin therapy .