Effect Study of Parecoxib to Treat Emergence Delirium and Postoperative Pain

Launched by FIRST AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY · Oct 13, 2010

Keywords

ClinConnect Summary

The inclusion criteria of this study includes:

* Aged older than 65;
* Primary elective abdominal surgery under general anesthesia;
* Ability to understand how to use pain assessment scales and PCA device.

The outcome measures of this study includes:

* Emergence Delirium Assessment;
* Pain intensity and pain relief efficacy endpoints;
* Tolerability and Safety Assessments

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged older than 65;
• • Body weight of at least 50 kg;
• • Primary elective abdominal surgery under general anesthesia;
• • Preoperative health graded as class ASA I-III, based on medical history and physical examination;
• • Ability to understand how to use pain assessment scales and PCA device
• Exclusion Criteria:
• • Emergency or revised abdominal surgery;
• • History of known use of analgesics or any other agent that could interfere with analgesic responses during the up to 24 h before receipt of the study medication which including NSAIDs, tricyclic antidepressants, neuroleptic or antipsychotic agents, or corticosteroids (except routine preoperative medication);
• • History of known or suspected drug abuse;
• • Known allergy, sensitivity, or contraindication to opioid and non-opioid analgesic drugs;
• • History of bleeding disorders, peptic ulceration, or anticoagulant use within the past month;
• • History of asthma or bronchospasm;
• • History of inflammatory bowel disease, a chronic or acute renal or hepatic disorder, coronary heart disease;
• • History of dementia and psychological disorder;
• • Contraindication to parecoxib.