Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery
Launched by NATIONAL CANCER INSTITUTE (NCI) · Jan 8, 2011
Trial Information
Current as of June 19, 2025
Active, not recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at two different treatments for patients with high-risk melanoma that has been surgically removed. Specifically, it compares the effectiveness of ipilimumab, an immunotherapy that helps the body’s immune system fight cancer, with high-dose interferon alfa-2b, which may slow the growth of cancer cells. The goal is to determine which treatment works better for patients who are at high risk for melanoma recurrence after surgery.
To be eligible for this trial, patients must have melanoma at specific stages (IIIB, IIIC, or IV) and show no signs of disease after their surgery, confirmed by imaging tests like PET scans or MRIs. Participants should be in generally good health, without active infections or certain autoimmune diseases. If enrolled, patients can expect to receive one of the two treatments and will be monitored closely for any side effects. Additionally, the study emphasizes the importance of mental health support, especially for those with a history of depression, as both treatments can have significant side effects. Overall, this trial aims to find the best way to help patients stay cancer-free after surgery.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • All patients must have disease-free status documented by a complete physical examination and imaging studies within 4 weeks prior to randomization; imaging studies must include a total body positron emission tomography (PET)-computed tomography (CT) scan (with or without brain) and brain magnetic resonance imaging (MRI) or CT (if MRI is contraindicated); if PET-CT cannot be done, CT of neck, chest, abdomen, and pelvis should be done
- • If for some reason a CT cannot be done, an MRI may be done instead; any other imaging studies if performed (eg, bone scan) must show no evidence of disease
- * Patients must have primary cutaneous melanoma that belong to one of the following American Joint Commission on Cancer (AJCC) stages (2009 AJCC Melanoma Staging System):
- • Stage IIIB
- • T1-4b N1a M0
- • T1-4b N2a M0
- • T1-4b N1b M0
- • T1-4b N2b M0
- • T1-4b N2c M0
- • Stage IIIC
- • T1-4b N1b M0
- • T1-4b N2b M0
- • T1-4b N2c M0
- • Any T N3 M0
- • Stage IV
- • M1a
- • M1b
- • NOTE: patients with stage IV melanoma must have normal lactate dehydrogenase (LDH) and either distant skin, subcutaneous, lymph node, or lung metastases, but no other visceral metastases in order to be eligible; for patients with resected stage IV melanoma, LDH within the institutional upper limit of normal (ULN) must be documented within 4 weeks prior to randomization
- * Patients with disease recurrence after adequate surgical excision of the original primary cutaneous/unknown primary melanoma are allowed even if they don't fit the strict staging criteria, but only as follows:
- • Recurrence in a regional lymph node basin after a prior complete lymph node dissection; relapsed disease must be completely surgically resected with free margins
- • Recurrence in the form of in-transit or satellite metastases or distant skin/subcutaneous, nodal, or lung metastases that are completely surgically resected with free margins
- • Recurrence in a regional lymph node basin; relapsed disease must be completely surgically resected with free margins
- • Patients with unknown primary melanoma (Tx) who present with cutaneous, subcutaneous, nodal and/or lung metastases that are completely surgically resected with free margins are allowed; these patients are allowed even if they don't fit the strict staging criteria; for stage IV patients LDH within the institutional ULN must be documented within 4 weeks prior to randomization (M1c is not eligible)
- • NOTE: all subjects should be classified as IIIB, IIIC, M1a or M1b including subjects with disease recurrence after adequate surgical excision of the original primary melanoma; that is the treating team/physician investigator should review an overall TNM status (that includes primary tumor presentation and disease recurrence status) and provide a designation of IIIB, IIIC, M1a or M1b
- • Patients must be randomized within 84 days (12 weeks) of surgical resection; if more than one surgical procedure is required to render the patient disease-free, the patient must be randomized within 12 weeks of the last surgery
- • NOTE: patients with clinically positive lymph nodes for melanoma involvement or those with positive lymph nodes identified through lymphoscintigraphic and/or dye lymphographic techniques in the groin, axilla, or neck should have additional lymphadenectomy in those sites; the complete lymph node dissection procedure would be considered as the last surgery in counting the 84 days unless a subsequent surgical procedure(s) was clinically required to ensure the disease free status
- • Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
- • Given that serious adverse events may occur with ipilimumab and IFN-alpha and that these may impact a patient's wellbeing, it is possible that the occurrence of other serious adverse events (SAEs) may seriously impact an underlying state of mental depression and lead to suicidal ideation; therefore, patients should be carefully screened for depression at baseline and if there are indications or a history of depression it is strongly recommended that these patients be closely followed together with behavioral health or psychiatric medical support; patients with an established diagnosis of depression that, in the assessment of the investigator may make the administration of IFN-alpha or ipilimumab hazardous, should not be enrolled on this protocol; the risks and benefits of being treated with standard adjuvant IFN-alpha should be weighed very carefully in consultation with behavioral health or psychiatry
- • Due to the possible effect of treatment with ipilimumab on the immunologic response to infectious disease vaccines, patients must not have had any infectious disease vaccination (e.g., standard influenza, H1N1 influenza, pneumococcal, meningococcal, tetanus toxoid) within 4 weeks prior to randomization
- • WOCBP must be using an adequate method of contraception to avoid pregnancy throughout the study and for up to 26 weeks after the last dose of ipilimumab or HDI, in such a manner that the risk of pregnancy is minimized; women who are using oral contraceptives, other hormonal contraceptives (vaginal products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing abstinence or where their partner is sterile (e.g., vasectomy) should be considered to be of childbearing potential
- • Men of fathering potential and WOCBP must be using an adequate method of contraception to avoid conception/pregnancy throughout the study and for up to 26 weeks after the last dose of ipilimumab or HDI in such a manner that the risk of pregnancy is minimized; men or WOCBP who are unwilling or unable to strictly follow this requirement are not eligible
- * WOCBP are not eligible if they satisfy any of the following:
- • A positive pregnancy test at baseline
- • Pregnant or breastfeeding
- • White blood cell (WBC) \>= 3,000/uL (obtained within 4 weeks prior to randomization)
- • Absolute neutrophil count (ANC) \>= 1,500/uL (obtained within 4 weeks prior to randomization)
- • Platelets \>= 100 x 10\^3/uL (obtained within 4 weeks prior to randomization)
- • Hemoglobin \>= 10 g/dL (obtained within 4 weeks prior to randomization)
- • Serum creatinine =\< 1.5 mg/dL (obtained within 4 weeks prior to randomization)
- • Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =\< 2.5 x ULN (obtained within 4 weeks prior to randomization)
- • Serum bilirubin =\< 1.5 x ULN, (except patients with Gilbert's syndrome, who must have a total bilirubin less than 3.0 mg/dL) (obtained within 4 weeks prior to randomization)
- • No active or chronic infection with human immunodeficiency virus (HIV), hepatitis B, or hepatitis C due to the unknown effects of ipilimumab; patients must have negative testing for HIV, hepatitis B virus (HBV), hepatitis C virus (HCV) within 4 weeks prior to randomization
- Exclusion Criteria:
- • Patients must not have received any adjuvant treatment (chemotherapy, biotherapy, or limb perfusion) after the resection(s) that make(s) them eligible for this trial
- • NOTE: previous radiation therapy, including after the surgical resection, is allowed as long as 21 days have elapsed between the radiation and initiation of this adjuvant systemic therapy
- • Prior treatment with anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) monoclonal antibodies or prior CTLA-4 inhibitor or agonist or prior clusters of differentiation (CD)137 agonist or prior interferon-alfa is not allowed; other forms of prior treatment for melanoma (e.g., aldesleukin \[IL-2\], anti-tumor vaccine, chemotherapy) are allowed if given before the resection(s) that make(s) the patient eligible for this trial, but these must have been completed at least 4 weeks prior to randomization
- • Patients must not have an active infection requiring current treatment with parenteral antibiotics
- • Patients must not have other significant medical, surgical, or psychiatric conditions or require any medication or treatment that in the opinion of the investigator may interfere with compliance, make the administration of ipilimumab or HDI hazardous or obscure the interpretation of adverse events (AEs), such as a condition associated with frequent diarrhea; patients with a baseline of frequent diarrhea (e.g. irritable bowel syndrome) are not eligible because of the difficulty in interpreting later expected GI toxicities that may lead to suboptimal management and complications
- • Patients must not have a documented history of inflammatory bowel disease (including ulcerative colitis and Crohn's disease) or diverticulitis (history of diverticulosis is allowed)
- • Patients must not have autoimmune disorders or conditions of immunosuppression that require current ongoing treatment with systemic corticosteroids (or other systemic immunosuppressants), including oral steroids (i.e., prednisone, dexamethasone) or continuous use of topical steroid creams or ointments or ophthalmologic steroids; a history of occasional (but not continuous) use of steroid inhalers is allowed; replacement doses of steroids for patients with adrenal insufficiency are allowed; patients who discontinue use of these classes of medication for at least 2 weeks prior to randomization are eligible if, in the judgment of the treating physician investigator, the patient is not likely to require resumption of treatment with these classes of drugs during the study
- • Exclusion from this study also includes patients with a history of symptomatic autoimmune disease (e.g., rheumatoid arthritis, systemic progressive sclerosis \[scleroderma\], systemic lupus erythematosus, Sjogren's syndrome, autoimmune vasculitis \[e.g., Wegener's granulomatosis\]); motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and Myasthenia Gravis); other central nervous system (CNS) autoimmune disease (e.g., poliomyelitis, multiple sclerosis)
- • Patients with autoimmune hypothyroid disease or type I diabetes on replacement treatment are eligible
- • Patients must not be prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious) illness; this is due to concerns about subject safety and compliance with study procedures
- • Patients who have other current malignancies are not eligible; patients with other malignancies are eligible if they have been continuously disease free for \> 5 years prior to the time of randomization; patients with prior history at any time of any in situ cancer, lobular carcinoma of the breast in situ, cervical cancer in situ, atypical melanocytic hyperplasia or melanoma in situ are eligible; patients with prior history of basal or squamous skin cancer are eligible; patients who have had multiple primary melanomas are eligible
- • Women must not be pregnant or breast-feeding due to the unknown effects of ipilimumab and HDI on conception and the fetus; all females of childbearing potential must have a blood test or urine study during screening to rule out pregnancy
- * NOTE: a woman of childbearing potential (WOCBP) is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); post-menopause is defined as:
- • Amenorrhea \>= 12 consecutive months without another cause, or
- • For women with irregular menstrual periods and taking hormone replacement therapy (HRT), a documented serum follicle stimulating hormone (FSH) level \>= 35 mIU/mL
About National Cancer Institute (Nci)
The National Cancer Institute (NCI) is a prominent component of the National Institutes of Health (NIH), dedicated to advancing cancer research and improving patient outcomes through innovative clinical trials. As a leading sponsor of cancer-related studies, NCI focuses on facilitating the development of new therapies, enhancing prevention strategies, and understanding the biology of cancer. The institute collaborates with academic institutions, healthcare providers, and industry partners to conduct rigorous clinical trials that aim to translate scientific discoveries into effective treatments. NCI’s commitment to fostering a robust research environment supports the mission to eliminate cancer as a major health problem.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
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Portland, Oregon, United States
Abington, Pennsylvania, United States
East Stroudsburg, Pennsylvania, United States
Scranton, Pennsylvania, United States
Scranton, Pennsylvania, United States
West Reading, Pennsylvania, United States
Wynnewood, Pennsylvania, United States
Sioux Falls, South Dakota, United States
American Fork, Utah, United States
Cedar City, Utah, United States
Murray, Utah, United States
Saint George, Utah, United States
Salt Lake City, Utah, United States
Seattle, Washington, United States
Tacoma, Washington, United States
Tacoma, Washington, United States
Vancouver, Washington, United States
Eau Claire, Wisconsin, United States
Eau Claire, Wisconsin, United States
Fond Du Lac, Wisconsin, United States
Green Bay, Wisconsin, United States
Green Bay, Wisconsin, United States
Green Bay, Wisconsin, United States
Manitowoc, Wisconsin, United States
Marinette, Wisconsin, United States
Marshfield, Wisconsin, United States
Minocqua, Wisconsin, United States
Oconomowoc, Wisconsin, United States
Oconto Falls, Wisconsin, United States
Rhinelander, Wisconsin, United States
Rice Lake, Wisconsin, United States
Sheboygan, Wisconsin, United States
Stevens Point, Wisconsin, United States
Sturgeon Bay, Wisconsin, United States
Waukesha, Wisconsin, United States
West Allis, Wisconsin, United States
Weston, Wisconsin, United States
Greenville, North Carolina, United States
Mountain View, California, United States
Palo Alto, California, United States
San Francisco, California, United States
Aurora, Colorado, United States
Colorado Springs, Colorado, United States
Denver, Colorado, United States
Lakewood, Colorado, United States
Wheat Ridge, Colorado, United States
Stamford, Connecticut, United States
Jacksonville, Florida, United States
Savannah, Georgia, United States
Cedar Rapids, Iowa, United States
Burlington, Massachusetts, United States
Danvers, Massachusetts, United States
Hamilton, New Jersey, United States
Albuquerque, New Mexico, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Marietta, Ohio, United States
Newark, Ohio, United States
Springfield, Ohio, United States
Westerville, Ohio, United States
Wooster, Ohio, United States
Zanesville, Ohio, United States
Chattanooga, Tennessee, United States
Bellingham, Washington, United States
Seattle, Washington, United States
Tacoma, Washington, United States
Huntington, West Virginia, United States
Antigo, Wisconsin, United States
Madison, Wisconsin, United States
Wausau, Wisconsin, United States
Ottawa, Ontario, Canada
Toronto, Ontario, Canada
Orlando, Florida, United States
Libertyville, Illinois, United States
Niles, Illinois, United States
Skokie, Illinois, United States
York, Maine, United States
Livonia, Michigan, United States
East Syracuse, New York, United States
Winston Salem, North Carolina, United States
Sioux Falls, South Dakota, United States
Bremerton, Washington, United States
Kennewick, Washington, United States
Mount Vernon, Washington, United States
Seattle, Washington, United States
Wenatchee, Washington, United States
Toronto, Ontario, Canada
Daytona Beach, Florida, United States
Kailua, Hawaii, United States
Clackamas, Oregon, United States
Newberg, Oregon, United States
Oshkosh, Wisconsin, United States
Munster, Indiana, United States
Littleton, Colorado, United States
New Ulm, Minnesota, United States
Albuquerque, New Mexico, United States
Los Angeles, California, United States
Pensacola, Florida, United States
Boise, Idaho, United States
Charleston, West Virginia, United States
Denver, Colorado, United States
Denver, Colorado, United States
Kitchener, Ontario, Canada
Manchester, Connecticut, United States
Moline, Illinois, United States
Portsmouth, New Hampshire, United States
East Orange, New Jersey, United States
Middletown, New York, United States
Utica, New York, United States
Independence, Ohio, United States
Norton, Virginia, United States
Tucson, Arizona, United States
Elkhart, Indiana, United States
Elkhart, Indiana, United States
Mishawaka, Indiana, United States
Plymouth, Indiana, United States
Westville, Indiana, United States
Saint Joseph, Michigan, United States
Las Vegas, Nevada, United States
Elgin, Illinois, United States
Honolulu, Hawaii, United States
Louisville, Kentucky, United States
Grand Junction, Colorado, United States
Boca Raton, Florida, United States
Athens, Georgia, United States
Overland Park, Kansas, United States
Baton Rouge, Louisiana, United States
Goldsboro, North Carolina, United States
Canton, Illinois, United States
Carthage, Illinois, United States
Eureka, Illinois, United States
Havana, Illinois, United States
Kewanee, Illinois, United States
Macomb, Illinois, United States
Monmouth, Illinois, United States
Monmouth, Illinois, United States
Normal, Illinois, United States
Peru, Illinois, United States
Princeton, Illinois, United States
Spring Valley, Illinois, United States
Springfield, Illinois, United States
Orange Park, Florida, United States
Palatka, Florida, United States
Boise, Idaho, United States
Baltimore, Maryland, United States
Stuart, Florida, United States
Elk Grove Village, Illinois, United States
Hines, Illinois, United States
Rockford, Illinois, United States
Indianapolis, Indiana, United States
Waterloo, Iowa, United States
Middletown, New York, United States
New York, New York, United States
Appleton, Wisconsin, United States
Parker, Colorado, United States
Winston Salem, North Carolina, United States
La Jolla, California, United States
Denver, Colorado, United States
Warrenville, Illinois, United States
Shreveport, Louisiana, United States
Niles, Michigan, United States
Lake Success, New York, United States
Grafton, Wisconsin, United States
Orange, California, United States
Poughkeepsie, New York, United States
Huntington, West Virginia, United States
Greenville, South Carolina, United States
Greenville, South Carolina, United States
Greenville, South Carolina, United States
Grand Blanc, Michigan, United States
Columbia, Missouri, United States
Grand Island, Nebraska, United States
Fort Smith, Arkansas, United States
Colorado Springs, Colorado, United States
Edwards, Colorado, United States
Lakeland, Florida, United States
Valdosta, Georgia, United States
Post Falls, Idaho, United States
Bloomington, Illinois, United States
Chicago, Illinois, United States
Chicago, Illinois, United States
Geneva, Illinois, United States
Pekin, Illinois, United States
Hays, Kansas, United States
Hutchinson, Kansas, United States
Liberal, Kansas, United States
Covington, Louisiana, United States
Monroe, Louisiana, United States
Scarborough, Maine, United States
Flint, Michigan, United States
Mount Clemens, Michigan, United States
Bolivar, Missouri, United States
Branson, Missouri, United States
New York, New York, United States
Concord, North Carolina, United States
Barberton, Ohio, United States
Lawton, Oklahoma, United States
Oklahoma City, Oklahoma, United States
Bend, Oregon, United States
Kittanning, Pennsylvania, United States
Williamsport, Pennsylvania, United States
Boiling Springs, South Carolina, United States
Easley, South Carolina, United States
Greenville, South Carolina, United States
Greenville, South Carolina, United States
Greer, South Carolina, United States
Seneca, South Carolina, United States
Saint George, Utah, United States
Poulsbo, Washington, United States
Spokane, Washington, United States
Burlington, Wisconsin, United States
Germantown, Wisconsin, United States
Green Bay, Wisconsin, United States
Kenosha, Wisconsin, United States
Marinette, Wisconsin, United States
Milwaukee, Wisconsin, United States
Milwaukee, Wisconsin, United States
Racine, Wisconsin, United States
Summit, Wisconsin, United States
Two Rivers, Wisconsin, United States
Waukesha, Wisconsin, United States
Wauwatosa, Wisconsin, United States
Wisconsin Rapids, Wisconsin, United States
Auburn, California, United States
Cameron Park, California, United States
Roseville, California, United States
Vacaville, California, United States
Peoria, Illinois, United States
Newark, Delaware, United States
Rockville, Maryland, United States
Bloomington, Illinois, United States
Downers Grove, Illinois, United States
Muncie, Indiana, United States
Kansas City, Missouri, United States
Wheeling, West Virginia, United States
Santa Rosa, California, United States
Fruitland, Idaho, United States
Fairbanks, Alaska, United States
Arroyo Grande, California, United States
Vacaville, California, United States
Whittier, California, United States
Denver, Colorado, United States
Lafayette, Colorado, United States
Stuart, Florida, United States
Stuart, Florida, United States
Chicago, Illinois, United States
Normal, Illinois, United States
River Forest, Illinois, United States
Indianapolis, Indiana, United States
Indianapolis, Indiana, United States
Owensboro, Kentucky, United States
Pittsfield, Massachusetts, United States
Marquette, Michigan, United States
Jefferson City, Missouri, United States
Omaha, Nebraska, United States
Albany, New York, United States
Troy, New York, United States
Cincinnati, Ohio, United States
Oklahoma City, Oklahoma, United States
Longview, Washington, United States
Seattle, Washington, United States
Montreal, Quebec, Canada
Chicago, Illinois, United States
Moline, Illinois, United States
Detroit, Michigan, United States
Tucson, Arizona, United States
Jonesboro, Arkansas, United States
Little Rock, Arkansas, United States
Antioch, California, United States
Fresno, California, United States
Modesto, California, United States
Sunnyvale, California, United States
Honolulu, Hawaii, United States
Lihue, Hawaii, United States
Fruitland, Idaho, United States
Lewiston, Idaho, United States
Meridian, Idaho, United States
Nampa, Idaho, United States
Twin Falls, Idaho, United States
West Des Moines, Iowa, United States
Great Bend, Kansas, United States
Kansas City, Kansas, United States
Overland Park, Kansas, United States
New Orleans, Louisiana, United States
Clarkston, Michigan, United States
Farmington Hills, Michigan, United States
Flint, Michigan, United States
Lapeer, Michigan, United States
Kansas City, Missouri, United States
Kansas City, Missouri, United States
Lee's Summit, Missouri, United States
Rolla, Missouri, United States
Rolla, Missouri, United States
Monroe, North Carolina, United States
Fargo, North Dakota, United States
Beachwood, Ohio, United States
Columbus, Ohio, United States
Portsmouth, Ohio, United States
Strongsville, Ohio, United States
Norman, Oklahoma, United States
Oklahoma City, Oklahoma, United States
Oregon City, Oregon, United States
The Dalles, Oregon, United States
Monroeville, Pennsylvania, United States
Natrona Heights, Pennsylvania, United States
Fredericksburg, Virginia, United States
Anacortes, Washington, United States
Bellevue, Washington, United States
Burien, Washington, United States
Edmonds, Washington, United States
Everett, Washington, United States
Issaquah, Washington, United States
Kirkland, Washington, United States
Lacey, Washington, United States
New Richmond, Wisconsin, United States
Sheboygan, Wisconsin, United States
Honolulu, Hawaii, United States
Post Falls, Idaho, United States
Wisconsin Rapids, Wisconsin, United States
Urbana, Illinois, United States
Randallstown, Maryland, United States
Rogers, Arkansas, United States
Springfield, Illinois, United States
Belpre, Ohio, United States
Columbus, Ohio, United States
Delaware, Ohio, United States
Longmont, Colorado, United States
Las Vegas, Nevada, United States
Great Falls, Montana, United States
Auburn, California, United States
Davis, California, United States
Santa Cruz, California, United States
Newark, Delaware, United States
Newark, Delaware, United States
Newark, Delaware, United States
Rehoboth Beach, Delaware, United States
Wilmington, Delaware, United States
Clive, Iowa, United States
West Des Moines, Iowa, United States
Manhattan, Kansas, United States
Minneapolis, Minnesota, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Voorhees, New Jersey, United States
Clinton, North Carolina, United States
Jacksonville, North Carolina, United States
Centerville, Ohio, United States
Delaware, Ohio, United States
Lancaster, Ohio, United States
Lewisburg, Pennsylvania, United States
Colorado Springs, Colorado, United States
Durango, Colorado, United States
Golden, Colorado, United States
Lakewood, Colorado, United States
Parker, Colorado, United States
Pueblo, Colorado, United States
Thornton, Colorado, United States
Meridian, Idaho, United States
Nampa, Idaho, United States
Twin Falls, Idaho, United States
Lexington, Kentucky, United States
Kearney, Nebraska, United States
Seattle, Washington, United States
Boulder, Colorado, United States
Denver, Colorado, United States
Englewood, Colorado, United States
Greenwood Village, Colorado, United States
Littleton, Colorado, United States
Lone Tree, Colorado, United States
Altamonte Springs, Florida, United States
Kissimmee, Florida, United States
Orlando, Florida, United States
Winter Park, Florida, United States
Carbondale, Illinois, United States
Centralia, Illinois, United States
Danville, Illinois, United States
Decatur, Illinois, United States
Effingham, Illinois, United States
Mattoon, Illinois, United States
New Lenox, Illinois, United States
Ottawa, Illinois, United States
Yorkville, Illinois, United States
Michigan City, Indiana, United States
Crestview Hills, Kentucky, United States
Bonne Terre, Missouri, United States
Sainte Genevieve, Missouri, United States
Sullivan, Missouri, United States
Sunset Hills, Missouri, United States
Omaha, Nebraska, United States
Asheville, North Carolina, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Fairfield, Ohio, United States
Clackamas, Oregon, United States
Kingsport, Tennessee, United States
Fond Du Lac, Wisconsin, United States
Lone Tree, Colorado, United States
Berwyn, Illinois, United States
Ames, Iowa, United States
Boone, Iowa, United States
Fort Dodge, Iowa, United States
Jefferson, Iowa, United States
Marshalltown, Iowa, United States
Lincoln, Nebraska, United States
Lincoln, Nebraska, United States
Omaha, Nebraska, United States
Scottsbluff, Nebraska, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Auburn, New York, United States
Syracuse, New York, United States
Pottsville, Pennsylvania, United States
Rhinelander, Wisconsin, United States
Jonesboro, Arkansas, United States
Asheville, North Carolina, United States
Brevard, North Carolina, United States
Franklin, North Carolina, United States
Jacksonville, North Carolina, United States
Marion, North Carolina, United States
Spruce Pine, North Carolina, United States
Greer, South Carolina, United States
Lancaster, South Carolina, United States
Rock Hill, South Carolina, United States
Spartanburg, South Carolina, United States
Kingsport, Tennessee, United States
Honolulu, Hawaii, United States
Milwaukee, Wisconsin, United States
'Aiea, Hawaii, United States
Emporia, Kansas, United States
Garden City, Kansas, United States
Rockport, Maine, United States
Asheville, North Carolina, United States
Charleston, South Carolina, United States
Charleston, South Carolina, United States
Charleston, South Carolina, United States
Mount Pleasant, South Carolina, United States
Mukwonago, Wisconsin, United States
Liverpool, New York, United States
Rome, New York, United States
Clinton, North Carolina, United States
San Luis Obispo, California, United States
Brewer, Maine, United States
Seattle, Washington, United States
Sacramento, California, United States
Gilbert, Arizona, United States
Albemarle, North Carolina, United States
Los Angeles, California, United States
Palatka, Florida, United States
Springfield, Ohio, United States
Bozeman, Montana, United States
Greeley, Colorado, United States
Nampa, Idaho, United States
Alton, Illinois, United States
Springfield, Illinois, United States
Grand Island, Nebraska, United States
Toledo, Ohio, United States
Waterloo, Iowa, United States
Aurora, Colorado, United States
Pekin, Illinois, United States
Normal, Illinois, United States
Kansas City, Missouri, United States
Macon, Georgia, United States
Elk Grove Village, Illinois, United States
Des Moines, Iowa, United States
Kalispell, Montana, United States
Lebanon, New Hampshire, United States
Grand Rapids, Michigan, United States
Muskegon, Michigan, United States
Pontiac, Michigan, United States
Ann Arbor, Michigan, United States
Danville, Illinois, United States
Boone, Iowa, United States
Fort Dodge, Iowa, United States
Jefferson, Iowa, United States
Marshalltown, Iowa, United States
Ames, Iowa, United States
Rhinelander, Wisconsin, United States
Stevens Point, Wisconsin, United States
Minocqua, Wisconsin, United States
Columbia, Missouri, United States
Sunset Hills, Missouri, United States
Niles, Michigan, United States
Reed City, Michigan, United States
Saint Joseph, Michigan, United States
Des Moines, Iowa, United States
Clive, Iowa, United States
Lincoln, Nebraska, United States
Lansing, Michigan, United States
Grand Rapids, Michigan, United States
Loveland, Colorado, United States
Rockford, Illinois, United States
Hays, Kansas, United States
Escanaba, Michigan, United States
Saint Joseph, Michigan, United States
Jefferson City, Missouri, United States
Madison, Wisconsin, United States
Kinston, North Carolina, United States
Kirkland, Washington, United States
Silverdale, Washington, United States
Madison, Wisconsin, United States
Johnson Creek, Wisconsin, United States
Royal Oak, Michigan, United States
Johnson Creek, Wisconsin, United States
Dearborn, Michigan, United States
Farmington Hills, Michigan, United States
Troy, Michigan, United States
Saginaw, Michigan, United States
Camillus, New York, United States
Wheat Ridge, Colorado, United States
Detroit, Michigan, United States
Warren, Michigan, United States
Norton, Virginia, United States
Kearney, Nebraska, United States
Denver, Colorado, United States
Mount Vernon, Illinois, United States
Clive, Iowa, United States
Des Moines, Iowa, United States
Des Moines, Iowa, United States
Denver, Colorado, United States
Rolla, Missouri, United States
Daytona Beach, Florida, United States
Pittsburg, Kansas, United States
Littleton, Colorado, United States
Parker, Colorado, United States
Cape Girardeau, Missouri, United States
Westbrook, Maine, United States
Kearney, Nebraska, United States
Kitchener, Ontario, Canada
Patients applied
Trial Officials
Ahmad Tarhini
Principal Investigator
ECOG-ACRIN Cancer Research Group
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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