Effect of Eplerenone in Elderly Hypertensive Early Stage Chronic Kidney Disease (CKD) Patients

Launched by JICHI MEDICAL UNIVERSITY · Feb 23, 2011

Keywords

ClinConnect Summary

Chronic kidney disease (CKD) was reported to be affecting 11% of the all population. This number is much higher in the elderly population and may be as high as 30%. CKD is an independent risk factor of cardiovascular disease (CVD). This is called "Cardio-renal Continuum". The renin-angiotensin-aldosterone system (RAS) plays pivotal roles in both cardiovascular and renal functions.

The increased oxidative stress by activated RAS on vascular endothelium is one of important factor to development of Cardio-renal Continuum. The blockade of RAS by angiotensin I converting enzyme inhibitors (ACEI...

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Eligibility criteria

• Inclusion Criteria:
• • Clinical diagnosis of stage1(eGFR\>=90ml/min/1.73m2) and stage2 (eGFR 60- 89ml/min/1.73m2)chronic kidney disease
• • Clinical diagnosis of Hypertension (Blood pressure \>=140/90mmHg)
• • Elderly people(\>=65 years old)
• Exclusion Criteria:
• • The patients who are already taking eplerenone
• • Stage3(eGFR 30-60 ml/min/1.73m2),stage4(eGFR 15-30 ml/min/1.73m2)and stage5 (eGFR \<15 ml/min/1.73m2) CKD patients
• • The patients who are receiving hemodialysis or peritoneal dialysis
• • The patients who are taking itraconazole, ritonavir and nelfinavir
• • The patients who are taking potassium-sparing diuretics and potassium supplement
• • The patients who have hyperkalemia(\>=5.5mEq/ml)
• • Severe heart failure (\>=NYHA class III)
• • Insulin dependent diabetic mellitus or poor controlled insulin independent diabetic mellitus (\>=HbA1c 9.0\&)
• • Severe liver dysfunction (five folds increased AST or ALT than standard values)