Compare the Effect of DPP-IV Inhibitor or TZD on Glycemic Variability and Oxidative Stress in Patient With 2 Diabetes

Launched by KOREA UNIVERSITY ANAM HOSPITAL · Apr 19, 2011

Keywords

ClinConnect Summary

Activation of oxidative stress by glucose fluctuations plays a major role in the pathogenesis of diabetic complication. Dipeptidyl peptidase IV (DPP-IV), such as vildagliptin, enhances glucose-induced insulin secretion, decreases glucagon secretion, and reduces postprandial hyperglycemia and may also improve acute fluctuations of glucose. We believe that vildagliptin may exert an effect of decreasing oxidative stress by reducing glucose excursion.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female with age 18-80 years
• • Type 2 diabetes mellitus
• • On stable dose of metformin (more than 1000mg) for at least 1 month
• • HbA1c 7\~10%
• • Subjects on statins, ACE inhibitors, ARBs and antioxidants will be allowed as long as they are on stable doses of these compounds and the dosage is not changed during the course of study
• • BP under control - no change required to BP medications
• • Agreement to maintain prior diet \& exercise
• Exclusion Criteria:
• • Type 1 DM or Any kind of secondary DM
• • Pregnant or lactating women.
• • Treatment with sulfonylurea, α-glucosidase inhibitor, glinide, GLP-1 analogues, DPP-IV inhibitors or insulin therapy within 1 month prior to informed consent.
• • Treatment with rosiglitazone or pioglitazone within 3 months prior to informed consent.
• • HbA1c \<7% or \>10%
• • Uncontrolled hypertension ( BP \> 160/100 mmHg)
• • Congestive heart failure (NYHA class I to IV).