Study of Transdermal Fentanyl Patch to Treat Postoperative Pain in Total Knee Arthroplasty
Launched by KHON KAEN UNIVERSITY · May 5, 2011
Trial Information
Current as of May 15, 2025
Completed
Keywords
ClinConnect Summary
Total knee arthroplasty (TKA) has severe postoperative pain that prevents mobilization of patient. The best standard analgesia regimen is patient-control analgesia (PCA) which requires a PCA pump that is expensive.
Transdermal fentanyl patch (TFP)(50 mcg/hr) can release fentanyl into blood circulation at rate 50 mcg/hr for three days. It has slow onset of about 12-14 hours, so it's used to treat chronic pain, not popular for a cure of pain. If the investigators apply TFP at appropriate times, i.e. 12-14 hours before surgery, it may be used to treat acute postoperative pain.
If it can give...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients who were scheduled for TKA gave informed consent for inclusion
- Exclusion Criteria:
- • ASA class 3-4
- • Known allergy to any of the drugs to be used, eg. TFPs ,MO
- • History of substance or alcohol abuse, and tolerance or dependence on opioids
- • Can not use PCA
- • Contraindication for spinal anesthesia
About Khon Kaen University
Khon Kaen University is a leading research institution in Thailand, dedicated to advancing medical science and improving healthcare outcomes through innovative clinical trials. With a commitment to ethical research practices and community health, the university collaborates with various national and international partners to conduct studies across diverse fields, including public health, pharmaceuticals, and medical devices. By leveraging its multidisciplinary expertise and state-of-the-art facilities, Khon Kaen University aims to contribute valuable insights and evidence-based solutions that address pressing health challenges both locally and globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Khon Kaen, , Thailand
Patients applied
Trial Officials
Thepakorn Sathitkarnmanee, MD
Principal Investigator
Faculty of Medicine, Khon Kaen University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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