Single-dose Azithromycin for the Treatment of Yaws
Launched by LIHIR MEDICAL CENTRE · Jun 24, 2011
Trial Information
Current as of May 14, 2025
Completed
Keywords
ClinConnect Summary
Regulatory status: Investigational - Randomized Clinical Trial. Registered product for antibacterial therapy
BACKGROUND Penicillin remains the drug of choice for the treatment of endemic treponematoses including yaws. This type of treatment is effective and cheap. There are, however, some disadvantages: the pain associated with a large volume (4 ml) deep i.m. injection, a high prevalence of self-reported allergy to penicillin, structural and logistic problems related to a treatment based on injection of drugs.
Azithromycin, a macrolide antibiotic with a long (68 hours) half-life in tissue...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • All children 6 months to 15 years of age who present to LMC with suggestive skin lesions or joint pains and VDRL and TPHA testing are positive
- • Suggestive skin lesions defined as: Symptomatic \> 4 weeks, painless, a traumatic ulcers with raised margins. VDRL positive when titer of at least 1:16
- Exclusion Criteria:
- • Pregnancy
- • Less than 6 months of age
- • Known allergy to penicillin or macrolide
- • Use of antibiotics active against treponema during the preceding six months (penicillin-G-benzathine, ceftriaxone, azithromycin or doxycycline)
About Lihir Medical Centre
Lihir Medical Centre is a leading healthcare institution dedicated to advancing medical research and improving patient outcomes through innovative clinical trials. As a sponsor, the center focuses on a diverse range of therapeutic areas, leveraging state-of-the-art facilities and a multidisciplinary team of experienced professionals. Committed to ethical standards and regulatory compliance, Lihir Medical Centre collaborates with researchers, healthcare providers, and participants to ensure the integrity and success of its clinical studies, ultimately contributing to the development of new treatments and enhancing the quality of care in the communities it serves.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Kavieng, New Ireland Province, Papua New Guinea
Patients applied
Trial Officials
Quique Bassat, MD, PhD
Study Director
Centre for International Health Research/Hospital Clínic/University of barcelona
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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