Effect of Pentoxifylline on Proteinuria in Korean Type 2 Diabetic Patients
Launched by AJOU UNIVERSITY SCHOOL OF MEDICINE · Jun 24, 2011
Trial Information
Current as of April 29, 2025
Completed
Keywords
ClinConnect Summary
The investigators will recruit adults patients with type 2 diabetes aged over 20 years with spot urine albumin to creatinine ratio over 30mg/g in two consecutive measurements.
Enrolled patients will be randomly assigned to receive pentoxifylline (400mg three times daily) or placebo for 24 weeks.
Fasting blood and spot urine will be collected at baseline, 12 weeks and 24 weeks.
The investigators will evaluate the impact of pentoxifylline on proteinuria in type 2 diabetic patients.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • type 2 diabetes mellitus
- • age \>=20 years
- • spot urine albumin/creatinine ratio \> 30mg/g in two consecutive measurements
- • patients on ACE-inhibitor or ARB as an anti-hypertensive drug
- • blood pressure \<= 150/100 mmHg
- • HbA1c \<10%
- Exclusion Criteria:
- • taking insulin pentoxifylline, cilostazol, ketas, viagra in 3 months
- • ischemic heart disease, stroke, malignant disease, severe infection in 6 months
- • serum creatinine \> 2.0mg/dl
- • severe liver disease or AST, ALT \> 3\* ULM
- • taking systemic steroid in 1 month
- • pregnant or plan to become pregnant during the clinical trial
- • lactation
About Ajou University School Of Medicine
Ajou University School of Medicine is a leading academic institution dedicated to advancing medical research and education. Located in South Korea, the School of Medicine is renowned for its commitment to innovative clinical trials that aim to improve patient outcomes and enhance healthcare practices. With a focus on multidisciplinary collaboration, Ajou University fosters a research environment that integrates cutting-edge technologies and scientific inquiry. The institution is dedicated to ethical standards and regulatory compliance, ensuring the safety and welfare of participants in all clinical studies. Through its robust training programs and partnerships, Ajou University School of Medicine aims to contribute significantly to the global medical community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Suwon, , Korea, Republic Of
Patients applied
Trial Officials
Kwan-Woo Lee, PhD
Principal Investigator
Ajou University School of Medicine
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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