Diagnostic Value of sTREM-1 and PCT Level as Well as CPIS Score for Ventilator-Associated Pneumonia Among ICU Sepsis Patients

Launched by CHINESE PLA GENERAL HOSPITAL · Jul 29, 2011

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Eligibility criteria

• Inclusion Criteria:
• • （1）Male and female aged 18 years old and over;
• • （2）Fulfilled at least two criteria of systemic inflammatory response syndrome (a) core temperature higher than 38 °C or lower than 36 °C (b)respiratory rate above 20/min, or PCO2 below 32 mmHg (c) pulse rate above 90/min, and (d) white blood cell count greater than 12,000/μl or lower than \< 4,000/μl or less than 10% of bands.（3）Clinically suspected infection; （4）Fulfilled criteria of VAP diagnosis(a) after 48-72h endotracheal intubation, X-ray film displays new or progressive infiltrating focus; (b)The patient is in two of the following conditions: a. fever (temperature \>38 ℃ or higher than basal temperature; b. peripheral WBC count≥10×10∧9/L，or \<4×10∧9/L; c. appearance or increase of purulent respiratory tract secretion. Besides the diagnostic norms above, it is suggested that lower respiratory tract secretions be collected under the bronchoscope and half-quantitative etiological culture be carried out through the medium of BALF samples (diagnostic threshold value:104cfu/mL ).
• Exclusion Criteria:
• • (1) were under 18 years of age;
• • (2) had contracted VAP upon ICU admission or in less than 48h after being admitted;
• • (3) were suffering from acquired immunodeficiency syndrome;
• • (4)were suffering from polymorphonuclear granulocyte counts (\< 500 μL-1); - (5) died within 24h after being taken into the ICU, or refused to get involved in the study, or gave up treatment during the period of observation