Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma

Launched by UNIVERSITY OF WASHINGTON · Aug 4, 2011

Keywords

ClinConnect Summary

1. Overview This multi-center pilot trial is designed to determine the feasibility and safety of hypotensive resuscitation for the early resuscitation of patients with traumatic shock compared to standard fluid resuscitation. Blunt and penetrating trauma patients with a prehospital systolic blood pressure (SBP) ≤ 90 mmHg will be eligible. In the hypotensive resuscitation group, an intravenous line (IV) will be placed and a radial pulse will be palpated. If the radial pulse is present or the SBP is greater than or equal to 70, a 250 ml bag of normal saline will be hung and maintained at a ke...

Gender

ALL

Eligibility criteria

• Inclusion Criteria: Included will be those with:
• • Blunt or penetrating injury
• • Age ≥15yrs or weight ≥50kg if age is unknown
• • Prehospital SBP ≤ 90 mmHg
• Exclusion Criteria: Excluded will be those with:
• • Ground level falls
• • Evidence of severe blunt or penetrating head injury with a Glasgow Coma Scale (GCS) ≤ 8
• • Bilateral paralysis secondary to suspected spinal cord injury
• • Fluid greater than 250ml was given prior to randomization
• • Cardiopulmonary resuscitation (CPR) by Emergency Medicine Service (EMS) prior to randomization
• • Known prisoners
• • Known or suspected pregnancy
• • Drowning or asphyxia due to hanging
• • Burns over a Total Body Surface Area (TBSA) \> 20%
• • Time of call received at dispatch to study intervention \> 4 hours