A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis
Launched by HOFFMANN-LA ROCHE · Aug 8, 2011
Trial Information
Current as of June 07, 2025
Completed
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Diagnosis of multiple sclerosis, in accordance with the revised McDonald criteria (2010)
- • At least 2 documented clinical attacks within the last 2 years prior to screening or one clinical attack in the years prior to screening (but not within 30 days prior to screening)
- • Neurologic stability for greater than or equal to (\>/=) 30 days prior to both screening and baseline
- • Expanded Disability Status Scale (EDSS) score 0 to 5.5 inclusive
- Exclusion Criteria:
- • Primary progressive multiple sclerosis
- • Disease duration of more than 10 years in patients with EDSS score less than or equal to (\</=) 2.0 at screening
- • Contraindications for MRI
- • Known presence of other neurological disorders which may mimic multiple sclerosis
- • Pregnancy or lactation
- • Requirement for chronic treatment with systemic corticosteroids or immunosuppressants during the course of the study
- • History of or currently active primary or secondary immunodeficiency
- • History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies
- • Active infection, or history of or known presence of recurrent or chronic infection (for example, hepatitis B or C, Human Immunodeficiency Virus \[HIV\], syphilis, tuberculosis)
- • History of progressive multifocal leukoencephalopathy
- • Contraindications to or intolerance of oral or IV corticosteroids
- • Contraindications to Rebif or incompatibility with Rebif use
About Hoffmann La Roche
Hoffmann-La Roche, commonly known as Roche, is a global leader in biotechnology and pharmaceuticals, committed to advancing healthcare through innovative research and development. With a strong focus on oncology, immunology, infectious diseases, and central nervous system disorders, Roche leverages cutting-edge science to deliver transformative therapies and diagnostics. The company is dedicated to improving patient outcomes by conducting rigorous clinical trials and collaborating with healthcare professionals and organizations worldwide. Roche's unwavering commitment to precision medicine and personalized healthcare positions it at the forefront of the industry, driving progress in the quest for effective treatments and improved patient care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Kansas City, Kansas, United States
Houston, Texas, United States
Tampa, Florida, United States
Worcester, Massachusetts, United States
Rochester, New York, United States
Barcelona, , Spain
Denver, Colorado, United States
Dallas, Texas, United States
San Antonio, Texas, United States
Ottawa, Ontario, Canada
Palo Alto, California, United States
Montreal, Quebec, Canada
Golden Valley, Minnesota, United States
Orlando, Florida, United States
Atlanta, Georgia, United States
Toms River, New Jersey, United States
Paris, , France
Bergen, , Norway
Phoenix, Arizona, United States
San Antonio, Texas, United States
Heidelberg, , Germany
Teaneck, New Jersey, United States
Edegem, , Belgium
Abington, Pennsylvania, United States
Seattle, Washington, United States
Nashville, Tennessee, United States
Barcelona, , Spain
Swansea, , United Kingdom
Madrid, , Spain
Aguascalientes, , Mexico
Varazdin, , Croatia
Pula, , Croatia
Brno, , Czechia
Charlotte, North Carolina, United States
Izmir, , Turkey
Minsk, , Belarus
Sarasota, Florida, United States
Round Rock, Texas, United States
Bydgoszcz, , Poland
Saint Petersburg, , Russian Federation
Prairie Village, Kansas, United States
Detroit, Michigan, United States
Raleigh, North Carolina, United States
Cordova, Tennessee, United States
Belo Horizonte, Mg, Brazil
Greenfield Park, Quebec, Canada
Teplice, , Czechia
Reims, , France
Genova, Liguria, Italy
Alicante, , Spain
Hollywood, Florida, United States
Buenos Aires, , Argentina
Torrette Ancona, Marche, Italy
Warszawa, , Poland
Kazan, , Russian Federation
Pula, , Croatia
Maitland, Florida, United States
Tampa, Florida, United States
Lubbock, Texas, United States
Katowice, , Poland
Muenchen, , Germany
Sarajevo, , Bosnia And Herzegovina
Tuzla, , Bosnia And Herzegovina
Barnaul, , Russian Federation
Latham, New York, United States
Umeå, , Sweden
Banska Bystrica, , Slovakia
Scottsdale, Arizona, United States
Tucson, Arizona, United States
Long Beach, California, United States
Fort Collins, Colorado, United States
Fairfield, Connecticut, United States
Miami, Florida, United States
Indianapolis, Indiana, United States
Lexington, Kentucky, United States
Wellesley, Massachusetts, United States
Ann Arbor, Michigan, United States
Newark, New Jersey, United States
Teaneck, New Jersey, United States
New York, New York, United States
Patchogue, New York, United States
Stony Brook, New York, United States
Columbus, Ohio, United States
Greenville, South Carolina, United States
Knoxville, Tennessee, United States
San Antonio, Texas, United States
Ciudad De Buenos Airesa, , Argentina
Grodno, , Belarus
Vitebsk, , Belarus
Vitebsk, , Belarus
Rio De Janeiro, Rj, Brazil
Campinas, Sp, Brazil
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Calgary, Alberta, Canada
Edmonton, Alberta, Canada
Vancouver, British Columbia, Canada
Gatineau, Quebec, Canada
Montréal, Quebec, Canada
Zagreb, , Croatia
Zagreb, , Croatia
Havirov, , Czechia
Pardubice, , Czechia
Bron, , France
Dijon Cedex, , France
Lommé, , France
Toulouse, , France
Berlin, , Germany
Bonn, , Germany
Düsseldorf, , Germany
Essen, , Germany
Frankfurt, , Germany
Mittweida, , Germany
München, , Germany
Ulm, , Germany
Dublin 4, , Ireland
Roma, Lazio, Italy
Roma, Lazio, Italy
Milano, Lombardia, Italy
Montichiari, Lombardia, Italy
Biella, Piemonte, Italy
Acquaviva Delle Fonti, Puglia, Italy
San Giovanni Rotondo, Puglia, Italy
Cefalu, Sicilia, Italy
Ciudad De México, Mexico City (Federal District), Mexico
Tlalnepantla De Baz, Mexico City (Federal District), Mexico
Chihuahua, , Mexico
Culiacan, , Mexico
Guadalajara, , Mexico
Krakow, , Poland
Lodz, , Poland
Lodz, , Poland
Lublin, , Poland
Olsztyn, , Poland
Siemianowice śląskie, , Poland
Kirov, , Russian Federation
Nizniy Novgorod, , Russian Federation
Perm, , Russian Federation
Pyatigorsk, , Russian Federation
Saratov, , Russian Federation
Banska Bystrica, , Slovakia
Levoca, , Slovakia
Badalona, Barcelona, Spain
L'hospitalet De Llobregat, Barcelona, Spain
Girona, , Spain
Madrid, , Spain
Malaga, , Spain
Valencia, , Spain
Göteborg, , Sweden
Stockholm, , Sweden
Stockholm, , Sweden
Ankara, , Turkey
Istanbul, , Turkey
Istanbul, , Turkey
Istanbul, , Turkey
Kocaeli, , Turkey
Samsun, , Turkey
Trabzon, , Turkey
Chernihiv, , Ukraine
Dnipropetrovsk, , Ukraine
Donetsk, , Ukraine
Donetsk, , Ukraine
Ivano Frankivsk, , Ukraine
Exeter, , United Kingdom
London, , United Kingdom
Stoke On Trent, , United Kingdom
Greenfield Park, Quebec, Canada
Fort Collins, Colorado, United States
Katowice, , Poland
Dallas, Texas, United States
Atlanta, Georgia, United States
Hickory, North Carolina, United States
Bergen, , Norway
Stockholm, , Sweden
Vitebsk, , Belarus
Ponderano, Piemonte, Italy
Badalona, Barcelona, Spain
Chernihiv, , Ukraine
Siemianowice ?L?Skie, , Poland
Teplice, , Czechia
Vitebsk, Vitsyebskaya Voblasts', Belarus
Culiacán Rosales, Sinaloa, Mexico
Kazan, Tatarstan, Russian Federation
Grodno, Hrodzyenskaya Voblasts', Belarus
Vitebsk, Vitsyebskaya Voblasts', Belarus
Guadalajara, Jalisco, Mexico
Barnaul, Altaj, Russian Federation
Sankt Peterburg, Sankt Petersburg, Russian Federation
Pyatigorsk, Stavropol, Russian Federation
Patients applied
Trial Officials
Clinical Trials
Study Director
Hoffmann-La Roche
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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