Modulation of Abeta Levels by GSK933776 in Alzheimer's Disease Patient

Launched by GLAXOSMITHKLINE · Aug 25, 2011

Keywords

ClinConnect Summary

This is a phase I, an open label, single dose and parallel group study to assess short term pharmacodynamics and safety of GSK933776. The effect on the beta amyloid levels will be assessed in early (MCI) and mild Alzheimer's disease (AD) patients after a single dose of GSK933776 by i.v. administration.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Probable mild Alzheimer's disease (MMSE 20-26) or mild cognitive impairment
• • Increase in total tau or p-tau in CSF
• • Decrease in amyloid beta in CSF
• • Stable dose of cholinesterase inhibitors, memantine or selegine or no treatment
• • Body weight less than 120 kg
• • Willingness to comply with contraceptive methods if self or partner is of child-bearing potential
• Exclusion Criteria:
• • Any other cause of dementia
• • Other significant neurologic or psychiatric illness
• • Hachinski Ischemia Score \>4
• • More than 3 microbleeds on MRI
• • Type 2 diabetes not controlled by diet
• • Risk of cerebrovascular disease, cerebral haemorrhage or stroke
• • History of systemic autoimmune disease
• • Use of platelet anti-aggregates or anti-coagulants (Aspirin up to 325 mg/day is allowable)
• • Use of chronic corticosteroids
• • Uncontrolled hypertension in spite of antihypertensive medications
• • Renal or hepatic insufficiency or clinically significant anaemia
• • In nursing home care
• • Contraindications to lumbar puncture or MRI
• • Prior participation in therapeutic studies only after adequate wash-out period