Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic Rhinosinusitis
Launched by MAHIDOL UNIVERSITY · Sep 6, 2011
Trial Information
Current as of May 01, 2025
Completed
Keywords
ClinConnect Summary
Chronic rhinosinusitis (CRS) is characterized by symptoms \> 12 weeks
Two or more symptoms one of which should be either nasal blockage /obstruction/congestion or nasal discharge (anterior/posterior nasal drip):
* facial pain/pressure
* reduction or loss of smell)
Mainstay of treatment are medical and surgical treatment ( ATB, adenoidectomy, ESS) Adjunctive treatment : normal saline nasal irrigation, nasal corticosteroids, nasal decongestants, mucolytics Topical antibiotic therapy in patients with refractory sinusitis has been shown to improve symptoms, quality of life, and mucosal aspec...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Chronic rhinosinusitis patients who were followed in pediatrics allergy clinic at Siriraj hospital between January 1, 2005, and February 28, 2011
- • Gentamicin nasal irrigation usage for longer than 3 months
- Exclusion Criteria:
- • Patients who used azithromycin prophylaxis within 1 year before and 6 months after started gentamicin nasal irrigation
- • Patients received IVIG within 1 year before and 6 months after started gentamicin nasal irrigation
- • Patients underwent endoscopic sinus surgery within 1 year before and 6 months after started gentamicin nasal irrigation
- • Patients received IT within 1 year before and 6 months after started gentamicin nasal irrigation
About Mahidol University
Mahidol University, a premier institution in Thailand, is dedicated to advancing healthcare through innovative research and education. As a leading sponsor of clinical trials, the university leverages its extensive expertise in medical and health sciences to facilitate rigorous scientific investigations aimed at improving patient care and public health outcomes. With a commitment to ethical practices and collaboration, Mahidol University fosters multidisciplinary approaches, engaging a diverse array of researchers and healthcare professionals to drive meaningful advancements in clinical research.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bangkoknoi, Bangkok, Thailand
Patients applied
Trial Officials
Nualanong Visitsunthorn, professor
Principal Investigator
Department of Pediatrics Faculty of Medicine Siriraj Hospital, Mahidol University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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