Is Cerazette Use Before Nexplanon Insertion Predictive for Bleeding Pattern?

Launched by VL-MEDI OY · Sep 21, 2011

Keywords

ClinConnect Summary

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Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Healthy women, 18-40 years of age
• • regular menstrual cycle (period 23-35 days)
• Exclusion Criteria:
• • -Immediate previous use of progestin only contraception within 2 months
• • Known or suspected pregnancy
• • Acute tromboembolic disorder
• • Presence or history of hepatic disease, as long as the liver function values have not returned to normal
• • Undiagnosed vaginal bleeding
• • Known or suspected sex-steroid influenced malignancies (e.g. breast cancer)
• • Hypersensitivity to the active substances or to any of the excipients of the medicines
• • Pregnant or breast feeding within 6 weeks
• • The use of other medicinal products that might interact with contraceptive steroids and affect the efficacy of contraceptives and/or might may lead to bleeding irregularities (especially medicines that induce the liver enzyme systems such as cytochrome P450). Examples of active substances are: phenytoin, phenobarbital, primidone, bosentan, carbamatzepine, rifampicin and medicinal products or herbal preparations containing ST.John's wort and to a lesser extend oxcarbazepine, topiramate, felbamate and griseofulvin.