Iron Absorption From Iron-fortified Fonio Porridge: a Stable Isotope Study

Launched by WAGENINGEN UNIVERSITY · Sep 29, 2011

Keywords

ClinConnect Summary

Objective: To compare the bioavailability of iron in fonio porridge fortified with isotopically enriched \[57Fe\] or \[58Fe\]-ferrous sulfate with and without reducing phytic acid by native phytase in wheat flour.

Study population: Sixteen apparently healthy young women aged 18-30 years recruited at the University based on their willingness to participate and according to inclusion criteria.

Study design: Fonio porridges fortified with isotopically labelled \[57Fe\] or \[58Fe\] ferrous sulfate, with (test meal) and without wheat flour (control meal) are administered to fasting subjects on...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • age 18 - 30 y-old
• • apparently healthy
• • body weight \< 65 kg (confirmed by anthropometric measurement at recruitment)
• • not pregnant (confirmed by pregnancy test)
• • not lactating (confirmed by age of last child if any)
• • no reported chronic medical illnesses (diabetes, rheumatism, high blood pressure, etc)
• • no reported symptoms of malaria in the last 2 months (fever, headache, stomachache, diarrhoea, nausea, vomiting) (confirmed by malaria test)
• • No severe anemia (Hb\<90 g/l)
• • no intake of vitamin and mineral supplements in the last 2 weeks
• • no iron medication or supplementation during the study
• • no blood donation in the last 6 months
• • no reported allergy to gluten
• Exclusion Criteria:
• • body weight (\> 65 kg)
• • pregnant
• • recent fever malaria
• • abnormal CRP level (\>10 mg/l)
• • severe anemia (Hb \< 90g/l) and iron deficiency (serum ferritin concentration \< 12 µg/l)