Effects of FODMAPs on Small Bowel Water Content: an MRI Study

Launched by UNIVERSITY OF NOTTINGHAM · Oct 24, 2011

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ClinConnect Summary

Title: Effects of FODMAPs (Fermentable Oligo-, Di-, and Mono-saccharides, And Polyols) on small bowel water content: an MRI study

1. Background. FODMAPs consist of fructose, lactose, fructo- and galacto-oligosaccharides such as fructans and galactans, and polyols such as sorbitol and mannitol. These carbohydrates are poorly absorbed in the small intestine and have been shown to trigger symptoms of irritable bowel syndrome (IBS). Previous studies have shown that fructose malabsorption results in an increased osmotic load in the small bowel, which can have a laxative effect. Physical proof o...

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Eligibility criteria

• Inclusion Criteria:
• • Apparently healthy: no medical conditions which might effect study measurements.
• • No reported participation in another nutritional or biomedical trial 3 months before the pre-study examination or during the study.
• • Age ≥ 18 and ≤ 60 year at pre-study investigation.
• • Body mass index (BMI) ≥ 18.0 and ≤ 30.0 kg/m2
• • No reported participation in night shift work two days prior to pre-study investigation or during the study. Night work is defined as working between midnight and 6.00 AM.
• • Strenuous exercise ≤ 10 hours per week.
• • Gender: male or female
• • Consumption of ≤ 21 alcoholic drinks in a typical week
• • Currently not smoking
• • Suitable for MRI scanning (e.g., absence of metal implants, infusion pumps and pacemakers) as assessed by the attached MRI safety questionnaire.
• Exclusion Criteria:
• • - use of medication which interferes with study measurements or bowel motility (as judged by the study physician).
• • Antibiotics in the 3 weeks before pre-study examination
• • Probiotics or during the study