Norfloxacin Versus Ciprofloxacin for Spontaneous Bacterial Peritonitis (SBP) Prevention
Launched by KOREA UNIVERSITY · Mar 1, 2012
Trial Information
Current as of May 21, 2025
Completed
Keywords
ClinConnect Summary
Spontaneous bacterial peritonitis (SBP) is one of the most serious complication of liver cirrhosis.
The short term mortality reaches 20-30% mainly due to sepsis, hepatorenal syndrome, and liver failure. In addition, patients who suffered SBP show poor prognosis with 1 year-mortality of 50-70%. The high recurrence rate is also problematic. Therefore appropriate prevention of SBP is critically needed to improve survival as well as quality of life.
Selective intestinal decontamination (SID) is eradicating gram negative bacterial in the gut lumen, and effectively prevent development of SBP. P...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age between 20-75 years old
- • Liver cirrhosis with ascites
- • Ascitic polymorphonucleated cells (PMN) count \< 250/mm3
- • Ascitic protein \<= 1.5 g/dL or History of SBP
- Exclusion Criteria:
- • Incompatibility with inclusion criteria
- • Hypersensitivity or intolerability with quinolones
- • Hepatocellular carcinoma beyond Milan Criteria
- • Hepatic encephalopathy over stage 2
- • History of treatment with antibiotics within 2 weeks of enrollment
- • HIV infection
- • Untreated malignancy
- • Women with child-bearing age not willing to use effective contraception.
- • Pregnant or breast feeding women
- • Not able to give informed consents
About Korea University
Korea University is a prestigious academic institution renowned for its commitment to advancing medical research and education. As a clinical trial sponsor, Korea University leverages its extensive resources and expertise to conduct innovative studies aimed at enhancing healthcare outcomes. The university fosters collaboration among leading researchers, medical professionals, and industry partners to drive the development of new therapies and interventions. With a focus on ethical standards and patient safety, Korea University is dedicated to contributing valuable insights to the scientific community and improving the quality of life for patients both locally and globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Seoul, , Korea, Republic Of
Ansan, Gyeonggi Do, Korea, Republic Of
Bucheon, , Korea, Republic Of
Cheonan, , Korea, Republic Of
Daegu, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Patients applied
Trial Officials
Soon Ho Um, M.D., Ph.D.
Principal Investigator
Korea University Anam Hospital
Hyung Joon Yim, M.D., Ph.D.
Study Director
Korea University Ansan Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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