Appetite Hormones in Binge Eating Disorder

Launched by NEW YORK OBESITY AND NUTRITION RESEARCH CENTER · Mar 9, 2012

Keywords

ClinConnect Summary

The objectives are to study appetite-related hormones regulating food intake under normal conditions and following a stressor in the morning and evening (when most binge episodes occur), to help reveal biological mechanisms in BED. We plan to enroll: 32 obese Ss with BED (16m, 16f), 32 obese Ss without BED (16m, 16f) and 32 normal-weight Ss without BED (16m, 16f). Height, weight, waist circumference, and body fat will be assessed during a first appointment. On two different days separated by at least a week, Ss will ingest a fixed liquid meal once in the morning and once in the evening. App...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI of 20-25 or 30-50
• • stable weight(± 4%) for at least 3 mo
• • premenopausal and have regular menstrual cycles (28 d ± 5), not be pregnant or lactating, and not be within 1 y of childbirth
• • must like pizza and be willing to consume it during the ad libitum meal
• Exclusion Criteria:
• • significant medical or psychiatric conditions
• • current and past 3-mo use of certain prescribed medications, especially those that could affect body weight, such as antidepressants and stimulants as well as smoking, or excess alcohol (\> 3 drinks/d)
• • vigorously exercise for more than 6 h/wk
• • left-handed, with known claustrophobia for a scanner enclosure, or have metal implants, non-removable metallic dental retainers, pacemakers, or permanent eyeliner or large tattoos that contain metallic pigment