Selective Laser Photocoagulation of Communicating Vessels in Twin-Twin Transfusion Syndrome

Launched by UNIVERSITY OF SOUTH FLORIDA · Jun 13, 2012

Keywords

ClinConnect Summary

No description provided

Gender

FEMALE

Eligibility criteria

• • Inclusion Criteria
• To be eligible, patients must meet the following criteria:
• • 1. Maternal age 18 to 55 years
• • 2. Gestational age: 16 weeks, 0 days to 26 weeks, 0 days.
• 3. Confirmed TTTS patients, who by definition meet the following sonographic criteria:
• • 1. Single placenta.
• • 2. Polyhydramnios: maximum vertical pocket \>= 8 cm in the recipient twin, prior to amniodrainage.
• • 3. Oligohydramnios: maximum vertical pocket \<=2 cm in the donor twin, prior to amniodrainage.
• • 4. Thin dividing membrane (absence of twin peak sign) or absence of dividing membrane (monoamniotic).
• • 5. Same gender, if visible.
• • 4. Patients choosing laser therapy that have undergone prior therapeutic amniocentesis may be included.
• • 5. Patients with an anterior placenta may be included.
• • 6. Triplet gestations with two or three fetuses sharing the same placenta may be included.
• • 7. Patients must be able to give written informed consent. Inclusion Criteria 5.2 Exclusion Criteria
• The following criteria would exclude patients from participation in the study:
• • 1. Patients unable or unwilling to participate in the study or to be followed up.
• • 2. Patients unable to give written informed consent.
• • 3. Presence of major congenital anomalies that may not warrant surgery.
• • 4. Known unbalanced chromosomal complement.
• • 5. Prior intentional septostomy (purposely making a hole in the dividing membrane).
• • 6. Ruptured membranes.
• • 7. Chorioamnionitis.
• • 8. Abnormal intracranial ultrasound findings of either fetus to include, but not limited to: intraventricular hemorrhage, porencephalic cysts, hydrocephalus, Dandy-Walker syndrome, holoprosencephaly and agenesis of the corpus callosum. Isolated ventriculomegaly (atrium 10-19 mm) may or may not be used an exclusion criteria.
• • 9. Placental abruption.
• • 10. Active labor.
• • 11. Jehovah's Witness.
• • 12. Any other patient deemed inappropriate for the study by the principal investigator.