Mode of Action of Moviprep

Launched by UNIVERSITY OF NOTTINGHAM · Jun 15, 2012

Keywords

ClinConnect Summary

Routine examinations of the colon including colonoscopy and barium enema widely carried out in clinical practice require evacuation of colonic contents. This is most conveniently carried out using osmotic laxatives the most widely used preparation being based on polyethylene glycol such as Moviprep. When fully made up as 1 litre of Moviprep , it provides 100 grams of polyethlene glycol '3350' with a measured osmolarity of around 530 mosmol/l. Being nonnutrient, this would be expected to rapidly leave the stomach and generate a substantial inflow of fluid in the upper small intestine as wate...

Gender

ALL

Eligibility criteria

• Inclusion Criteria Group 1 and 2:
• • Male or female healthy volunteers who are 18-65 years
• • BMI 18-28 kg/m2
• • Able to give voluntary written informed consent to participate in the study
• • Able to understand the requirements of the study, including anonymous publication, and agree to co-operate with the study procedures
• Inclusion Criteria Group 3:
• • Male or female who are 18-65 years
• • BMI 18-30 kg/m2
• • Able to give voluntary written informed consent to participate in the study
• • Able to understand the requirements of the study, including anonymous publication, and agree to co-operate with the study procedures
• • Patient diagnosed with constipation predominant irritable bowel syndrome who failed to respond to at least 1 laxative treatment in the past
• • Patient diagnosed with functional constipation who failed to respond to 1-2 sachets of Movicol per day
• Exclusion Criteria for group 1 and 2:
• • Any history of serious acute or chronic illness especially gastrointestinal
• • Diabetes Mellitus
• • Pregnancy or breast feeding
• • Smoking
• • Unsuitable for MRI scanning (i.e. have metal implants or a pace maker)
• • Regular use of medication interfering with gastrointestinal function including opiates or constipating drugs
• • Subjects using the oral contraceptive pill will be excluded if not prepared to use an alternative barrier method of contraception for the duration of the menstrual cycle following dosing with Moviprep
• • Substance abuse
• • Have taken part in another clinical study within the previous 3 months
• • Previous gastrointestinal surgery of any kind apart from appendicectomy
• Exclusion criteria for group 3:
• • Any history of serious acute or chronic illness especially gastrointestinal
• • Diabetes Mellitus
• • Pregnancy or breast feeding
• • Unsuitable for MRI scanning (i.e. have metal implants or a pace maker)
• • Regular use of medication interfering with gastrointestinal function including opiates or constipating drugs
• • Subjects using the oral contraceptive pill will be excluded if not prepared to use an alternative barrier method of contraception for the duration of the menstrual cycle following dosing with Moviprep
• • Substance abuse
• • Have taken part in another clinical study within the previous 3 months
• • Previous gastrointestinal surgery of any kind apart from appendicectomy/cholecystectomy