Physiological Study to Determine the Allergic Skin Activity After Different Skin Preparation

Launched by UNIVERSITY OF ZURICH · Jun 25, 2012

Keywords

ClinConnect Summary

BACKGROUND INFORMATION The prevalence of allergic diseases has been continuously increasing, reaching a prevalence of up to 30% in industrialized countries. In Switzerland, about 2 million people are affected by IgE-mediated allergies as reported by the Swiss Center for Allergy, Skin and Asthma and the Swiss Society for Allergology and Immunology (SSAI). By subcutaneous injections of gradually increasing allergen doses, conventional subcutaneous SIT (SCIT) is found to reduce the inappropriate T-helper (Th) 2 responses and IgE production. Due to the risk of systemic allergic side effects, th...

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Eligibility criteria

• Inclusion criteria:
• • Written informed consent
• • 18-65 years old (male and female)
• • A positive clinical history for inhalant allergy presumably due to birch pollen
• • Positive screening prick test (mean wheal diameter = 3mm) to birch pollen allergen solution
• • A mean wheal size of = 7mm2 obtained in the screening prick test with histamine dihydrochloride (10mg/ml)
• Exclusion criteria:
• • Impaired in understanding the nature, meaning and scope of the study or incapable of giving written informed consent
• • Participation in another clinical trial within the last 30 days and during the present study
• • Pregnancy or nursing
• • Positive skin reaction in the screening prick test to NaCl
• • Currently suffering from allergy symptoms
• • History of systemic reactions to allergens
• • Severe diseases influencing the results of the present study by discretion of the investigator
• • Immunotherapy with the allergen preparation during the past two years
• • Skin lesions and excessive hair-growth in the skin test areas
• • Treatment with prohibited concomitant medications, with the exception of medications with local effects which will not influence the results of the skin prick tests
• • Alcohol or drug abuse