Antithrombotic Effects of Ticagrelor Versus Clopidogrel

Launched by JUAN J BADIMON · Jul 13, 2012

Keywords

ClinConnect Summary

The HORIZONS-AMI Trial compared the effectiveness of heparin plus a glycoprotein IIb/IIIa inhibitor (GPI) versus bivalirudin in acute myocardial infarction (AMI) patients undergoing stent deployment 1. Overall the data showed benefits associated with the bivalirudin treatment with lower rates of all-cause mortality, cardiac mortality, re-infarction and non-CABG related major bleeding; However, the data seems to indicate a non-significant increase in acute stent thrombosis in the bivalirudin group. This observation seems to suggest the potential benefits of adding an antiplatelet agent to bi...

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Eligibility criteria

• Inclusion Criteria:
• • Male or female volunteers between 18 and 65 years old.
• • Body mass index (BMI) 18 - 30 kg/m2 inclusive.
• • Healthy as assessed by a detailed medical history and physical examination.
• • Laboratory est results within the normal range.
• • Ability to provide signed informed consent.
• Exclusion Criteria:
• • History of clinically relevant disease, bleeding, acute infectious disease or signs of acute illness.
• • Allergy or hypersensitivity to aspirin or thienopyridines, or atopy diagnosed by a physician.
• • Use of medication within one month prior to study drug administration.
• • History of drug abuse or alcohol consumption \>20 g/day.
• • Inability to abstain from intensive muscular effort or sport competition.
• • Loss of \>400 mL blood or blood donation within 3 months.
• • Positive serology for hepatitis B (HBs Ag) or hepatitis C.
• • Conditions associated with hemorrhagic risk.
• • Positive pregnancy test.