Efficacy of the PARI LC Sprint Sp Nebulizer for Acute Asthma Attack in Hospitalized Children Less Than 36 Months of Age

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE NĪMES · Jul 24, 2012

Keywords

ClinConnect Summary

The secondary objectives of this study are to evaluate whether the use of the LC Sprint Sp Nebulizer results in:

A-shortened duration of oxygen-dependence.

B-reduced side effects by assessing the patient's heart rate before and 30 minutes after the first aerosol and noting the occurrence of desaturation \<90% during the nebulisation sessions.

C-increased acceptance of the aerosol, measured via a questionnaire given to the patient's parents at the end of hospitalization (a single questionnaire will be completed by either parent or both parents).

D-shortened length of stay based on the fo...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The parent or legal representative must have given his/her informed and signed consent
• • The patient must be insured or beneficiary of a health insurance plan
• * The patient has an attack of moderate to severe asthma (at least the third episode of wheezing dyspnea since birth) requiring hospitalization defined by the following criteria:
• • requires oxygen: SpO2 \<92% on room air (if CAS ≤ 4/10)
• • And / or CAS\> 4/10 (after 3 attempted nebulized salbutamol sessions over 1 hour of emergency care).
• Exclusion Criteria:
• • The patient is participating in another study
• • The patients has already been included in this study a previous time
• • The patient is in an exclusion period determined by a previous study
• • The patient is under judicial protection, under tutorship or curatorship
• • The parent or legal representative refuses to sign the consent
• • It is impossible to correctly inform the parent or legal representative
• • The patient has a contra indication for a treatement used in this study
• • Patient was born at \< 34 weeks of pregnancy or bronchdysplasic
• • First or second episode of bronchiolitis
• • Asthma attack with CAS score ≤ 4/10 or inpatient basis for a non-breathing related motive.
• • Acute severe Asthma attack: hypercapnia, impaired consciousness, need for hospitalization in intensive care, need for mechanical ventilation, need for salbutamol IV
• • Patient with known congenital heart disease
• • Patient with chronic respiratory disease other than asthma
• • Patient with encephalopathy
• • Patient with known immune deficiency
• • CAS ≤ 2 and transcutaneous oxygen saturation (SpO2)\> 94% when awake or \> 91% when asleep for at least 12h