Comparison of Efficacy of Intralesional Triamcinolone Injection and Clobetasol Propionate Ointment for Psoriatic Nails

Launched by MAHIDOL UNIVERSITY · Oct 7, 2012

Keywords

ClinConnect Summary

Psoriasis is a chronic inflammatory disorder. The nails involvement has been reported up to 40% of psoriatic patients. Psoriatic nails can significantly affect a quality of life of patients. Psoriasis affects both nail matrix and nail bed. Pitting, leukonychia and red spots in lunula indicate a defect in the nail matrix. Psoriasis can change the nail bed as the results in onycholysis, discoloration, splinter hemorrhage and subungual hyperkeratosis. The main treatment of psoriatic nails is using topical high- potent steroids however topical steroids are limited their ability to penetrate dee...

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Eligibility criteria

• Inclusion Criteria:
• • Subjects aged over 18 years old who have at least 3 psoriatic finger nails resembly severity
• Exclusion Criteria:
• • 1. Patients are receiving the systemic therapy of psoriasis
• • 2. Patients discontinued the systemic therapy less than 3 months and topical therapy less than 1 month
• • 3. Positive results for the microscopic study of fungus in finger nails
• • 4. History of steroids or EMLA allergy
• • 5. Pregnancy or nursing
• • 6. Any skin infection at the site of the treatment
• • 7. Human immunodeficiency virus subjects
• • 8. History of malignancy or during the treatment of malignancy
• • 9. Patients who have psychological disorder
• • 10. Patients who have bleeding disorder or receiving anticoagulation drugs