Influence of Sperm With Large Nuclear Vacuole on ICSI Outcomes

Launched by SAPIENTIAE INSTITUTE · Nov 12, 2012

Keywords

ClinConnect Summary

A new method for the detailed morphological evaluation of motile spermatozoa in real time, under high magnification, named "motile sperm organellar morphology examination" (MSOME) was developed. This magnification provides an accurate description of spermatozoa abnormalities, particularly the presence of head vacuoles, which is indicative of abnormal chromatin packaging in spermatozoa. However, the influence of sperm with large nuclear vacuoles (SLV) on ART outcomes is still a matter of debate. The goals for this study were to identify whether there is a connection between SLV under high ma...

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Eligibility criteria

• Inclusion Criteria:
• • Couples undergoing intracytoplasmic sperm injection (ICSI) as result of male factor or tubal factor or unexplained infertility
• • Women with regular menstrual cycles of 25-35 days
• • Women with normal basal follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels
• • Women with body mass index (BMI) less than 30 kg/m2
• • Women with both ovaries and intact uterus
• Exclusion Criteria:
• • Women with polycystic ovaries syndrome
• • Women with endometriosis
• • Women with gynaecological/medical disorders
• • Couples with any sexually transmitted disease
• • Women who had received any hormone therapy for less than 60 days preceding the study