Tadalafil Effects in Left Ventricle Diastolic Dysfunction in Resistant Hypertensive Patients
Launched by UNIVERSITY OF CAMPINAS, BRAZIL · Dec 4, 2012
Trial Information
Current as of June 21, 2025
Completed
Keywords
ClinConnect Summary
Resistant hypertensive patients have a high incidence of left ventricle diastolic dysfunction (LVDD). Lowering blood pressure levels improves diastolic function, however, there is no proved effective treatment specifically for this disease. Studies in hypertensive rats have shown presence of phosphodiesterase-5 in cardiac cells and an improvement in left ventricle diastolic function using a phosphodiesterase-5 (PDE5) inhibitor, the sildenafil. PDE5 has also been demonstrated in human heart cells with cardiac disease. In addition, LVDD is associated with high levels of brain natriuretic pept...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • resistant hypertension (according to Resistant Hypertension - American Heart Association Statement - 2008);
- • compliance with antihypertensive treatment;
- • age \>35 years;
- • left ventricle diastolic dysfunction types I and II
- Exclusion Criteria:
- • valvulopathy
- • decompensated heart failure
- • important cardiac arrhythmias
- • nephropathy
- • hepatopathy
- • autoimmune disease
- • tabagism
- • decompensated diabetes
- • uncontrolled dislipidemia
About University Of Campinas, Brazil
The University of Campinas (Universidade Estadual de Campinas, UNICAMP) is a prestigious research institution located in Brazil, renowned for its commitment to advancing knowledge and innovation in the medical and scientific fields. With a strong emphasis on interdisciplinary collaboration, UNICAMP conducts cutting-edge clinical trials aimed at improving healthcare outcomes and developing novel therapeutic approaches. The university leverages its extensive resources, including state-of-the-art laboratories and a team of highly qualified researchers and clinicians, to contribute significantly to the global body of medical research while fostering education and training in clinical and translational sciences.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Campinas, São Paulo, Brazil
Patients applied
Trial Officials
Heitor Moreno-Junior, MD, PhD
Principal Investigator
Faculty of Medical Sciences - Unicamp
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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