Hemodynamic Responses During Induction: Comparison of Marsh and Schnider Pharmacokinetic Models
Launched by FIRST AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY · Jan 1, 2013
Trial Information
Current as of June 03, 2025
Completed
Keywords
ClinConnect Summary
Current systems of propofol TCI are pre-programmed with the Marsh and Schnider pharmacokinetic models. Rate constants of Marsh are fixed, whereas compartment volumes and clearances are weight proportional. Schnider model has fixed values for VC, V3, k13, and k31, adjusts V2, k12, and k21 for age, and adjusts k10 according to total weight, lean body mass (LBM), and height. One major benefit of the Schnider model is that it adjusts doses and infusion rates according to patient age. This provides a strong argument for using the Schnider model in the elderly and unwell patients which may improve...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients between the ages of 18 years and 70 years
- • ASA physical status I and II
- • surgical procedures requiring general anesthesia with continuous CVP and arterial pressure monitoring.
- Exclusion Criteria:
- • Patients younger than 16 y or older than 65 y
- • Body Mass Index (BMI) \<18 or \>30
- • emergency surgery
- • allergy to any of the drugs used
- • inability to communicate effectively
- • severe cardiovascular dysfunction
- • patient refusal and patients on long-term opioids or sedative medication.
About First Affiliated Hospital, Sun Yat Sen University
The First Affiliated Hospital of Sun Yat-sen University is a prestigious medical institution located in Guangzhou, China, renowned for its commitment to advancing healthcare through innovative clinical research and comprehensive patient care. As a leading teaching hospital, it combines clinical excellence with academic rigor, facilitating a wide range of clinical trials across various specialties. The hospital is dedicated to improving health outcomes and contributing to medical knowledge, leveraging its state-of-the-art facilities and a team of highly qualified professionals to conduct high-quality research that adheres to international standards.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Guangzhou, Guangdong, China
Patients applied
Trial Officials
Xia Feng, M.D.
Principal Investigator
The First Affiliaed Hospital of Sun Yat-sen University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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