Magnetic Resonance Diagnostics of Diabetic Peripheral Neuropathy

Launched by AARHUS UNIVERSITY HOSPITAL · May 3, 2013

Keywords

ClinConnect Summary

Background

Diabetes mellitus is a very frequent disorder with an estimated prevalence of 275,000 patients in Denmark. Diabetic peripheral neuropathy (DPN) is a late complication which often remains undiagnosed, but may occur in up to 40% of diabetic patients. Advanced neuropathy may induce irreversible damages to the nervous tissue, and to avoid further damages, early diagnosis is important followed by optimal treatment of diabetes. DPN is a common complication due to long term diabetes in both type 1 and type 2.

Nerve conduction studies (NCS) is the gold standard method to diagnose DPN. ...

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Eligibility criteria

• Inclusion Criteria:
• • Clinical diagnosis of type 1 diabetes, without neuropathy
• • Clinical diagnosis of type 2 diabetes, without neuropathy
• • Clinical diagnosis of type 1 diabetes, with neuropathy
• • Clinical diagnosis of type 2 diabetes, with neuropathy
• • Clinical diagnosis of hereditary axonal neuropathy
• • Clinical diagnosis of hereditary demyelinised neuropathy
• • Healthy controls who do not use prescription drugs and are of normal weight (BMI between 20 and 30).
• Exclusion Criteria:
• • The second cause of the neuropathy.
• • Persons who are under 18.
• • Inability to perform nerve conduction study or magnetic resonance imaging.
• • Patients with liver disease, hypothyroidism, current or past alcohol abuse, rheumatological diseases and vasculitis.
• • Silver Treatment, in diabetics with wounds.