Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke

Launched by UNIVERSITY HOSPITAL, MARTIN · May 22, 2013

Keywords

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ischemic stroke
• • female or male gender
• • mRS (modified Rankin Scale) 0-1 (min one month before the event)
• • NIHSS ≥ 6 and ≤ 25
• • Age: 18-80 years
• • initiation of therapy in the interval from 4.5 to 24 hours from onset of symptoms of ischemic stroke
• • focal neurological deficit of at least 30 min, which was significantly obviously does not disappear before treatment
• • patient will participate voluntarily and signed informed consent. Informed consent will be obtained from each patient, guardian or close relative
• • patients who are unable to sign, but who are able to understand what means to participate in the study, may give informed consent through eyewitness
• • willingness and ability to comply with the protocol
• Exclusion Criteria:
• • intracranial hemorrhage confirmed by CT scan
• • CT image heavy and extensive focal cerebral ischemia
• • lacunar syndrome
• • epileptic seizure at the beginning of ischemic stroke
• • previous or planned treatment with intravenous, intra-arterial thrombolysis, mechanical recanalization or ultrasound assisted thrombolysis
• • stroke, myocardial infarction, head trauma in the last 3 months
• • tromboctov count below 100 000/mm ³
• • therapeutically uncontrolled blood pressure: systolic blood pressure\> 185 mmHg or diastolic blood pressure\> 110 mmHg
• • therapeutically uncontrolled blood glucose ˂ 2.77 or\> 22.15 mmol / l
• • Known bleeding diathesis, other coagulopathies, severe hepatopathy, severe nephropathy
• • patients receiving oral anticoagulants
• • current or previous life-threatening bleeding
• • major surgery less than 2 weeks ago
• • known malignancy
• • active TB
• • pregnancy
• • allergy to Heparin or Fraxiparine
• • known alcohol abuse and / or drugs
• • active participation in another clinical study