Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis

Launched by MCMASTER UNIVERSITY · Jun 20, 2013

Keywords

ClinConnect Summary

The processes of muscle protein synthesis (MPS) and muscle protein breakdown (MPB) occur concurrently. This constant protein turnover allows the muscle fiber to change its protein structure if loading demands or diet changes. The plasticity of skeletal muscle to respond to altered loading and contractile patterns is evidence of the capacity for remodeling that a fiber can undergo. It is quite well documented for example that mitochondrial content increases with endurance-type work. In contrast, heavier loading leads to less change in mitochondrial content but increases in myofibrillar prote...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Male
• • Healthy and physically active (as determined by medical and activity questionnaire)
• • 18-35 years of age
• • 70-90 kg body mass
• • Having given informed consent
• Exclusion Criteria:
• • Exhibiting health risk factors as identified on the health screening questionnaire
• • Having any identified metabolic or intestinal disorders
• • Tobacco use
• • Aspirin use in the 4 days prior to the experimental trial
• • Consumption of prescription medications or any performance enhancing agent
• • Inability to endure the strenuous exercise bouts e.g. injuries
• • Alcohol intake during the 48 hours prior to each of the testing days
• • Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study
• • Have given blood in the last three weeks
• • Verbal confirmation that they have used a substance on the WADA banned list within the last year