An Acute Human Intervention With Flavonoid to Investigate Absorption, Metabolism and Excretion

Launched by UNIVERSITY OF EAST ANGLIA · Aug 12, 2013

Keywords

ClinConnect Summary

The study will recruit men and women who are aged either 18-30 or 65-77 years and are generally healthy.On arriving at the study day we will collect a blood sample. Breakfast will then be supplied in the form of a food or drink that will contain freezedried powder from orange juice, chocolate and blackberry. After breakfast further blood samples will be taken at several time points throughout the day. Urine and faeces samples will also be collected. These biological samples will be tested for flavonoid absorption, metabolism and excretion as well as influence of genetic make-up of individua...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Male or Female
• • Caucasian of European origin
• • Age either between 18-30 years or between 65-77 years
• Exclusion Criteria:
• • BMI \< 18.5 kg/m2 or BMI \> 30 kg/m2
• • Smokers or nicotine users
• • High (above 140/90 mmHg ) or low (less than 90/60 mmHg) blood pressure
• • Having any existing medical conditions or significant past medical history likely to affect study measurements e.g., type 2 diabetes, cardiovascular, renal, liver or gastrointestinal diseases
• • Unsatisfactory biochemical, haematological or urinary assessment, indicating abnormal; renal or liver function, full blood profile, impaired glucose handling, deranged lipids or measurements considered to be counter indicative of the study by the clinical advisor
• • Taking any prescribed medication that could interact with the enzymes involved in the metabolism of flavonoids
• • Taking flavonoid containing supplements or other dietary supplements for one month prior to the study (and duration of the study intervention)
• • Known allergies to the intervention foods
• • Consume more alcoholic beverages on average than 21 units/wk for men, or 14 units/wk for women (The UK Department of Health recommendations)
• • Pregnant, breast feeding, or planning a pregnancy (or having fertility treatment)
• • Unable to provide informed consent to participate in the study