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Search / Trial NCT01958606

High Intensity Interval Training in Chronic Stroke

Launched by UNIVERSITY OF CINCINNATI · Oct 7, 2013

Trial Information

Current as of May 05, 2025

Completed

Keywords

Stroke Rehabilitation Exercise Intensity Gait

ClinConnect Summary

Participants were randomized to either HIT or traditional aerobic training; each 25 minutes, 3 times per week for 4 weeks. Outcomes were measured before and after training by a blinded rater.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 1) age 35-90 years
  • 2) unilateral stroke experienced \>6 months prior to enrollment
  • 3) able to walk 10m overground with assistive devices as needed and no physical assistance
  • 4) able to walk 3 minutes on the treadmill at \>.13m/s (0.3mph) with no aerobic exercise contraindications
  • 5) stable cardiovascular condition (American Heart Association class B, allowing for aerobic capacity \<6 metabolic equivalents)
  • 6) discharged from formal rehabilitation
  • Exclusion Criteria:
  • 1) significant resting ECG abnormalities
  • 2) evidence of significant arrhythmia or myocardial ischemia on treadmill ECG stress test
  • 3) hospitalization for cardiac or pulmonary disease within 3 months
  • 4) pacemaker or implanted defibrillator
  • 5) lower extremity claudication
  • 6) unable to communicate with investigators or correctly answer consent comprehension questions
  • 7) severe lower extremity spasticity (Ashworth \>2)
  • 8) lower extremity weight bearing pain \>4/10 on visual analogue scale
  • For the transcranial magnetic stimulation substudy, additional exclusions will also be applied. These include large cerebral infarcts or other structural defects with the potential to increase seizure risk, uncontrolled seizures, metal implants and previous craniotomy.

About University Of Cincinnati

The University of Cincinnati is a leading research institution dedicated to advancing healthcare through innovative clinical trials and studies. With a robust focus on translational research, the university fosters a collaborative environment that integrates cutting-edge science with clinical practice. Its diverse team of experts, equipped with state-of-the-art facilities, is committed to exploring new therapeutic interventions aimed at improving patient outcomes. The University of Cincinnati actively engages in partnerships with industry and academia to drive forward-thinking solutions in medicine, ensuring that research findings are effectively translated into real-world applications.

Locations

Cincinnati, Ohio, United States

Patients applied

0 patients applied

Trial Officials

Brett Kissela, MD

Principal Investigator

University of Cincinnati

Kari Dunning, PhD, PT

Principal Investigator

University of Cincinnati

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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