A Study of Atezolizumab Compared With Docetaxel in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Failed Platinum-Containing Therapy
Launched by HOFFMANN-LA ROCHE · Dec 6, 2013
Trial Information
Current as of June 16, 2025
Completed
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Locally advanced or metastatic (Stage IIIB, Stage IV, or recurrent) NSCLC
- • Representative formalin-fixed paraffin-embedded (FFPE) tumor specimens
- • Disease progression during or following treatment with a prior platinum-containing regimen for locally advanced, unresectable/inoperable or metastatic NSCLC or disease recurrence within 6 months of treatment with a platinum-based adjuvant/neoadjuvant regimen or combined modality (e.g., chemoradiation) regimen with curative intent
- • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1
- • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Exclusion Criteria:
- • Known active or untreated central nervous system (CNS) metastases
- • Malignancies other than NSCLC within 5 years prior to randomization, with the exception of those with a negligible risk of metastasis or death and treated with expected curative outcome
- • History of autoimmune disease
- • History of idiopathic pulmonary fibrosis (including pneumonitis), drug-induced pneumonitis, organizing pneumonia, or evidence of active pneumonitis on screening chest computed tomography (CT) scan. History of radiation pneumonitis in the radiation field (fibrosis) is permitted
- • Active hepatitis B or hepatitis C
- • Prior treatment with docetaxel
- • Prior treatment with cluster of differentiation 137 (CD137) agonists, anti-cytotoxic-T-lymphocyte-associated antigen 4 (anti-CTLA4), anti-programmed death-1 (anti-PD-1), or anti-PD-L1 therapeutic antibody or pathway-targeting agents
About Hoffmann La Roche
Hoffmann-La Roche, commonly known as Roche, is a global leader in biotechnology and pharmaceuticals, committed to advancing healthcare through innovative research and development. With a strong focus on oncology, immunology, infectious diseases, and central nervous system disorders, Roche leverages cutting-edge science to deliver transformative therapies and diagnostics. The company is dedicated to improving patient outcomes by conducting rigorous clinical trials and collaborating with healthcare professionals and organizations worldwide. Roche's unwavering commitment to precision medicine and personalized healthcare positions it at the forefront of the industry, driving progress in the quest for effective treatments and improved patient care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Minneapolis, Minnesota, United States
Providence, Rhode Island, United States
Harvey, Illinois, United States
Edmonton, Alberta, Canada
Windsor, Ontario, Canada
Long Beach, California, United States
Manchester, , United Kingdom
Missoula, Montana, United States
Minneapolis, Minnesota, United States
Norfolk, Virginia, United States
Peoria, Illinois, United States
Farmington, New Mexico, United States
Tacoma, Washington, United States
Bakersfield, California, United States
Atlanta, Georgia, United States
Laval, Quebec, Canada
Montreal, Quebec, Canada
Tampere, , Finland
Patras, , Greece
Auckland, , New Zealand
Porto, , Portugal
Majadahonda, Madrid, Spain
Madrid, , Spain
Madrid, , Spain
Madrid, , Spain
Malaga, , Spain
Bangkok, , Thailand
Bangkok, , Thailand
Caen, , France
Dunedin, , New Zealand
Vallejo, California, United States
London, , United Kingdom
Taichung, , Taiwan
London, , United Kingdom
Fairfax, Virginia, United States
Santa Maria, California, United States
Grenoble, , France
Hemer, , Germany
Berlin, , Germany
Aviano, Friuli Venezia Giulia, Italy
Salzburg, , Austria
Bordeaux, , France
Bari, Puglia, Italy
Quincy, Illinois, United States
Detroit, Michigan, United States
Warszawa, , Poland
Samara, , Russian Federation
Madrid, , Spain
Zaragoza, , Spain
Bangkok, , Thailand
Fullerton, California, United States
Oakland, California, United States
San Jose, California, United States
Walnut Creek, California, United States
Minneapolis, Minnesota, United States
Porto Alegre, Rs, Brazil
Guatemala City, , Guatemala
Gyeonggi Do, , Korea, Republic Of
La Coruña, , Spain
Hayward, California, United States
Heidelberg, , Germany
Paris, , France
Gdansk, , Poland
Seoul, , Korea, Republic Of
Bettendorf, Iowa, United States
Scarborough, Maine, United States
Milano, Lombardia, Italy
Oslo, , Norway
Panama, , Panama
Grimsby, , United Kingdom
Billings, Montana, United States
Strasbourg, , France
Seoul, , Korea, Republic Of
Moscow, , Russian Federation
Geneve, , Switzerland
Istanbul, , Turkey
Innsbruck, , Austria
Rosario, , Argentina
Roma, Lazio, Italy
Monza, Lombardia, Italy
Madrid, , Spain
'S Hertogenbosch, , Netherlands
Gyeonggi Do, , Korea, Republic Of
Baden, , Switzerland
Frankfurt, , Germany
Roanoke, Virginia, United States
Coimbra, , Portugal
Lisboa, , Portugal
Avignon, , France
Pecs, , Hungary
Taoyuan, , Taiwan
Buffalo, New York, United States
Sacramento, California, United States
Vancouver, Washington, United States
Henderson, Nevada, United States
Milano, Lombardia, Italy
Padova, Veneto, Italy
Las Palmas De Gran Canaria, Las Palmas, Spain
Taipei, , Taiwan
Taipei, , Taiwan
Lille, Nord, France
La Jolla, California, United States
San Luis Obispo, California, United States
Jacksonville, Florida, United States
Columbus, Ohio, United States
Creteil, , France
Marseille, , France
Toulon, , France
Immenhausen, , Germany
Pisa, Toscana, Italy
Aichi, , Japan
Chiba, , Japan
Fukuoka, , Japan
Miyagi, , Japan
Okayama, , Japan
Shizuoka, , Japan
Tokyo, , Japan
Tokyo, , Japan
Eindhoven, , Netherlands
Nieuwegein, , Netherlands
Roseville, California, United States
Sacramento, California, United States
Santa Clara, California, United States
South San Francisco, California, United States
Vöcklabruck, , Austria
Hamilton, , New Zealand
Luzern, , Switzerland
Dnipropetrovsk, , Ukraine
Las Vegas, Nevada, United States
Torokbalint, , Hungary
Miami, Florida, United States
Eugene, Oregon, United States
Grand Junction, Colorado, United States
Paris, , France
Gauting, , Germany
Regensburg, , Germany
Paris, , France
London, , United Kingdom
Avellino, Campania, Italy
Toulouse, , France
Paramus, New Jersey, United States
Osaka, , Japan
Seoul, , Korea, Republic Of
Oulu, , Finland
Sutton In Ashfield, , United Kingdom
Genova, Liguria, Italy
Belgrade, , Serbia
Sremska Kamenica, , Serbia
Orlando, Florida, United States
Tyler, Texas, United States
San Francisco, California, United States
London, , United Kingdom
Napoli, Campania, Italy
Seoul, , Korea, Republic Of
Rennes, , France
Mulhouse, , France
Pierre Benite, , France
Los Angeles, California, United States
San Marcos, California, United States
Halle, , Germany
Lodz, , Poland
Otwock, , Poland
Linköping, , Sweden
Vina Del Mar, , Chile
Burbank, California, United States
Northridge, California, United States
Redondo Beach, California, United States
Lone Tree, Colorado, United States
Omaha, Nebraska, United States
Florham Park, New Jersey, United States
Clifton Park, New York, United States
Tulsa, Oklahoma, United States
Austin, Texas, United States
Houston, Texas, United States
Milwaukee, Wisconsin, United States
Córdoba, , Argentina
Provincia De Buenos Aires, , Argentina
Recoleta, , Chile
Temuco, , Chile
Helsinki, , Finland
Besancon, , France
Le Mans, , France
Paris, , France
Pringy, , France
Suresnes, , France
Köln, , Germany
Athens, , Greece
Thermi Thessalonikis, , Greece
Budapest, , Hungary
Parma, Emilia Romagna, Italy
Udine, Friuli Venezia Giulia, Italy
Catania, Sicilia, Italy
Lucca, Toscana, Italy
Verona, Veneto, Italy
Ehime, , Japan
Hyogo, , Japan
Hyogo, , Japan
Osaka, , Japan
Saitama, , Japan
Tokyo, , Japan
Yamaguchi, , Japan
Poznan, , Poland
Saint Petersburg, , Russian Federation
Goeteborg, , Sweden
Stockholm, , Sweden
Izmir, , Turkey
Kharkiv, , Ukraine
Uzhgorod, , Ukraine
London, , United Kingdom
Patients applied
Trial Officials
Clinical Trials
Study Director
Hoffmann-La Roche
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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