Luteal Phase Versus Follicular Phase Administration of Clomiphene Citrate in PCOS, A Randomized Controlled Trial

Launched by AIN SHAMS MATERNITY HOSPITAL · Dec 29, 2013

Keywords

ClinConnect Summary

AIM OF THE WORK The study will compare the luteal phase (early) administration of clomiphene citrate to the conventional (late) administration of the same drug in the follicular phase as regards ovarian response in PCOS.

Research Question What is the difference between administration of clomiphene citrate in the luteal phase and the follicular phase for ovulation induction in women with PCOS? Research Hypothesis Luteal phase administration of clomiphene citrate protocol gives better results than conventional administration of clomiphene citrate in the follicular phase as regards ovarian re...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • A. Women aged 20-40 years old.
• B. Patients with diagnosis of PCOS based on the 2003 ESHRE/ASRM (Rotterdam) criteria: to include two of the following, in addition to exclusion of related disorders:
• • 1. Oligo / anovulation
• • 2. Hyperandrogenism and/or Hyperandrogenemia
• • 3. Polycystic ovaries by U/S i.e. at least one ovary showing either 1 - 12 more follicles (2-9 mm in diameter) or ovarian volume \> 10 mm.
• Exclusion Criteria:
• • A. Age \< 20 or \> 40. B. Major pelvic pathology. C. Ovarian masses. D. Infertility due to causes other than ovarian factors e.g.
• • 1. Bilateral tubal block
• • 2. Congenital anomaly of the uterus
• • 3. Male factor of infertility E. Liver disease F. Other endocrinopathies e.g. hyperprolactinemia, Lipoid Congenital Adrenal Hyperplasia (LCAH), hypothyroidism, hyperthyroidism and Cushing's disease.