Measurement of Retinal Nerve Fiber Layer Thickness - a Biomarker for the Early Detection of Alzheimer's Disease?

Launched by CARMEL MEDICAL CENTER · Jan 30, 2014

Keywords

ClinConnect Summary

Alzheimer's Disease (AD) is a degenerative neurological disorder characterized by the insidious onset of a progressive decline in cognitive function. It is the most common form of dementia affecting an estimated 26 million people worldwide in 2006, a number that is expected to quadruple by 2050 due to the anticipated increase in life expectancy. Difficulty remembering names and recent events is often an early clinical symptom as is apathy and depression. Later symptoms include impaired judgment, disorientation, confusion, behavior changes and difficulty in swallowing and walking.

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Eligibility criteria

• Inclusion Criteria:
• • age 60 and above
• • able to read, understand and sign independently a consent form
• • able to undergo a cognitive test
• • results of their cognitive test fall into one of the three cohort groups
• Exclusion Criteria:
• • other diseases affecting the optic nerve such as glaucoma
• • unclear media such as dense cataracts that will not allow assessment by OCT
• • Cognitive test scores that are less than mild cognitive impairment