Role of Endothelin-1 in Flow-mediated Dilatation

Launched by UNIVERSITY HOSPITAL, ROUEN · Mar 11, 2014

Keywords

ClinConnect Summary

No description provided

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Male, Caucasian, aged 18 to 35 years
• • Non-Smoking
• • Resting heart rate\> 50 and \<90 bpm
• • SBP \<140 mmHg and DBP \<90 mm Hg at rest in the supine position for 10 minutes
• • Normal ECG
• Exclusion Criteria:
• • Known allergy
• • Intolerance to glyceryl trinitrate
• • Intolerance to lidocaine
• • Family history of hypertension
• • Excessive alcohol consumption ( more than 50 g / day)
• • Addiction or presumption of illicit drug use
• • Subject refusing blood samples for serology of hepatitis B , C and HIV
• • History of illness or psychological or sensory abnormality that may prevent the subject to understand the requirements for participation in the protocol or prevents giving informed consent
• • Metabolic or endocrine disease
• • Immunological diseases
• • Renal or hepatic impairment
• • Ischemic or obstructive heart disease
• • Neoplastic disease
• • Gastrointestinal disease
• • Neurological disease , intracranial hypertension , seizure disorders
• • Compulsive overeating , bulimia, anorexia
• • Severe psychiatric illness
• • Presence of a clinically significant abnormality in laboratory tests carried out at the inclusion visit .
• • HBs Ag , HCV Ab , Ac HIV 1 or HIV 2 positive .
• • The use of any drug in the range of less than 5 half-life time, in particular betablockers, sildenafil, cimetidine, amiodarone .