Hyperpolarized Xenon Gas MR Imaging in NSCLC Radiotherapy

Launched by OXFORD UNIVERSITY HOSPITALS NHS TRUST · May 29, 2014

Keywords

ClinConnect Summary

Survival rates for lung cancer are poor. One year survival rate in the United Kingdon for males is 27% and for females 30%, falling to less than 10% at five years. Prognosis for lung cancer is so poor because over two thirds of patients are diagnosed at a late stage when curative treatment is not possible. Early diagnosis and assessment of tolerance for curative treatment would make a significant difference to survival rates.

Histologically, approximately 80% of lung cancer is nonsmall cell lung cancer (NSCLC). The main curative treatment for NSCLC is surgery. Radical radiotherapy and chem...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participant is willing and able to give informed consent for participation in the trial
• • Male or Female, aged 18 years or above
• • Histologically verified NSCLC
• • Patients with any stage NSCLC where radical radiotherapy (with either conventionally fractionated treatment or with stereotactic body radiotherapy (SABR)) or chemoradiotherapy (concurrent or sequential schedule) is considered appropriate
• • WHO performance status 0-2
• • Able (in the Investigators opinion) and willing to comply with all study requirements
• Exclusion Criteria:
• • Inability to give written informed consent
• • Female participant who is pregnant, lactating or planning pregnancy during the course of the trial
• • Previous radiotherapy to the chest
• • The presence of another condition where the disease itself or treatment may interfere with the study endpoints
• • Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
• • Inability to lie flat for imaging
• • Contraindications to MRI examination including indwelling pacemaker, non-MRI compatible metallic implant, severe claustrophobia, intra-ocular foreign body
• • Contraindications for gadolinium enhanced lung MRI scan - known hypersensitivity/allergy to the injection of MultiHance (contains gadobenate dimeglumine and small quantities of benzyl alcohol) that is given as part of this scanning or an adverse reaction to an injection given during previous MRI scanning, severe renal impairment
• • Contraindications for ventilation/perfusion nuclear medicine scanning - known hypersensitivity to albumin or preference to avoid blood donation product
• • Epilepsy requiring on-going medical treatment, or a seizure within the past year