Retinal Nerve Fiber Layer and Macular Thickness Changes During Pregnancy

Launched by THE BARUCH PADEH MEDICAL CENTER, PORIYA · Jun 1, 2014

Keywords

ClinConnect Summary

There are several known ophthalmic physiologic changes in pregnancy:

1. Refractive Change: progesterone-mediated changes in fluid content partially accounts for refractive change of lens and cornea; myopic shift of less than 1 D was observed in in 15% of participating pregnant women
2. Night vision decreased mainly with low serum vitamin A levels in pregnant women.
3. Fall of the IOP in second half of pregnancy (about 10% drop)
4. Corneal changes (increased thickness; decreased sensitivity) = contact lens intolerance

The retina and optic nerve are considered part of central nervous system...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1st trimester (6-14w) pregnant healthy women
• • No known medical problems related to their current pregnancy on recruitment
• • Age 18-45yrs
• • No known retinal or optic nerve disease
• • Refraction between +3.0 and -4.0 diopters
• • Agrees to participate in the study
• Exclusion Criteria:
• • Retinal or optic nerve disease
• • Refractive errors more than +3.0 and -4.0.
• • If already finished 14w gestation when recruited to the 1st OCT examination
• • Known to have HTN or DM before gestation
• • Ocular media abnormality that obscures OCT view or examination