A Study Comparing the Efficacy, Safety and Tolerability of Fixed Dose Combination (FDC) of FF/UMEC/VI With the FDC of FF/VI and UMEC/VI; Administered Once-daily Via a Dry Powder Inhaler (DPI) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Launched by GLAXOSMITHKLINE · Jun 12, 2014
Trial Information
Current as of May 28, 2025
Completed
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Informed Consent: A signed and dated written informed consent prior to study participation
- • Type of subject: Outpatient
- • Age: Subjects 40 years of age or older at Visit 1
- • Gender: Male or female subjects. A female is eligible to enter and participate in the study if she is of: Non-child bearing potential (i.e. physiologically incapable of becoming pregnant, including any female who is post-menopausal or surgically sterile). Surgically sterile females are defined as those with a documented hysterectomy and/or bilateral oophorectomy or tubal ligation. Post-menopausal females are defined as being amenorrhoeic for greater than 1 year with an appropriate clinical profile, e.g. age appropriate, \> 45 years, in the absence of hormone replacement therapy OR Child bearing potential, has a negative pregnancy test at screening, and agrees to one of the following acceptable contraceptive methods used consistently and correctly (i.e. in accordance with the approved product label and the instructions of the physician for the duration of the study - screening to safety follow-up contact): Abstinence; Oral Contraceptive, either combined or progestogen alone; Injectable progestogen; Implants of levonorgestrel; Estrogenic vaginal ring; Percutaneous contraceptive patches; Intrauterine device (IUD) or intrauterine system (IUS); Male partner sterilization (vasectomy with documentation of azoospermia) prior to the female subject's entry into the study, and this male is the sole partner for that subject. For this definition, "documented" refers to the outcome of the investigator's/designee's medical examination of the subject or review of the subject's medical history for study eligibility, as obtained via a verbal interview with the subject or from the subject's medical records. Double barrier method: condom and an occlusive cap (diaphragm or cervical/vault caps) with a vaginal spermicidal agent (foam/gel/film/cream/suppository)
- • COPD Diagnosis: An established clinical history of COPD in accordance with the definition by the American Thoracic Society/European Respiratory Society
- • Smoking History: Current or former cigarette smokers with a history of cigarette smoking of \>=10 pack-years at screening (visit 1) \[number of pack years = (number of cigarettes per day / 20) x number of years smoked (e.g., 20 cigarettes per day for 10 years, or 10 cigarettes per day for 20 years)\]. Previous smokers are defined as those who have stopped smoking for at least 6 months prior to Visit 1. Note: Pipe and/or cigar use cannot be used to calculate pack-year history
- • Severity of COPD symptoms: A score of \>=10 on the COPD Assessment Test (CAT) at screening
- • Severity of COPD Disease: A post-albuterol/salbutamol FEV1/ Forced Vital Capacity (FVC) ratio of \<0.70 at Screening
- • Existing COPD maintenance treatment: Subject must be receiving daily maintenance treatment for their COPD for at least 3 months prior to Screening. Note: Subjects receiving only Pro re nata (PRN) COPD medications are not eligible
- • History of Exacerbations: Subjects must demonstrate: a post-bronchodilator FEV1 \<50% predicted normal and a documented history of \>= 1 moderate or severe COPD exacerbation in the previous 12 months OR a post-bronchodilator 50% \<=FEV1 \< 80% predicted normal and a documented history of \>= 2 moderate exacerbations or a documented history of \>=1 severe COPD exacerbation (hospitalized) in the previous 12 months. Note: Percent predicted will be calculated using the European Respiratory Society Global Lung Function Initiative reference equations. Note: A documented history of a COPD exacerbation (e.g., medical record verification) is a medical record of worsening COPD symptoms that required systemic/oral corticosteroids and/or antibiotics (for a moderate exacerbation) or hospitalization (for a severe exacerbation). Prior use of antibiotics alone does not qualify as an exacerbation history unless the use was associated with treatment of worsening symptoms of COPD, such as increased dyspnea, sputum volume, or sputum purulence (color). Subject verbal reports are not acceptable
- • Liver function tests: alanine aminotransferase (ALT) \<2x upper limit of normal (ULN); alkaline phosphatase \<=1.5xULN; bilirubin \<=1.5xULN (isolated bilirubin \>1.5 x ULN is acceptable if bilirubin is fractionated and direct bilirubin \<35%)
- • French subjects: In France, a subject will be eligible for inclusion in this study only if either affiliated to or a beneficiary of a social security category
- Exclusion Criteria:
- • Pregnancy: Women who are pregnant or lactating or are planning on becoming pregnant during the study
- • Asthma: Subjects with a current diagnosis of asthma. (Subjects with a prior history of asthma are eligible if they have a current diagnosis of COPD)
- • Alpha1-antitrypsin deficiency: Subjects with Alpha1-antitrypsin deficiency as the underlying cause of COPD
- • Other respiratory disorders: Subjects with active tuberculosis, lung cancer, significant bronchiectasis, sarcoidosis, lung fibrosis, pulmonary hypertension, interstitial lung diseases or other active pulmonary diseases
- • Lung resection: Subjects with lung volume reduction surgery within the 12 months prior to Screening
- • Risk Factors for Pneumonia: immune suppression (e.g. human immunodeficiency virus \[HIV\], Lupus) or other risk factors for pneumonia (e.g. neurological disorders affecting control of the upper airway, such as Parkinson's Disease, Myasthenia Gravis). Patients at potentially high risk (e.g. very low BMI, severely malnourished, or very low FEV1) will only be included at the discretion of the Investigator
- • Pneumonia and/or moderate or severe COPD exacerbation that has not resolved at least 14 days prior to Screening and at least 30 days following the last dose of oral/systemic corticosteroids (if applicable). In addition, any subject that experiences pneumonia and/or moderate or severe COPD exacerbation during the run-in period will be excluded
- • Other Respiratory tract infections that have not resolved at least 7 days prior to screening
- • Abnormal Chest x-ray(CXR): Chest x-ray (posteroanterior and lateral) reveals evidence of pneumonia or a clinically significant abnormality not believed to be due to the presence of COPD, or another condition that would hinder the ability to detect an infiltrate on CXR (e.g. significant cardiomegaly, pleural effusion or scarring). All subjects will have a chest x-ray at Screening Visit 1 (or historical radiograph or computerised tomography (CT) scan obtained within 3 months prior to screening) that will be over-read by a central vendor. Note: Subjects who have experienced pneumonia and/or moderate or severe COPD exacerbation within 3 months of screening must provide a post pneumonia/exacerbation chest x-ray to be over-read by the central vendor or have a chest x-ray conducted at screening. For sites in Germany: If a chest x-ray (or CT scan) within 3 months prior to Screening (Visit 1) is not available, approval to conduct a diagnostic chest x-ray will need to be obtained from the Federal Office for Radiation Protection (Bundesamt für Strahlenschutz \[BfS\])
- • Other diseases/abnormalities: Subjects with historical or current evidence of clinically significant cardiovascular, neurological, psychiatric, renal, hepatic, immunological, gastrointestinal, urogenital, nervous system, musculoskeletal, skin, sensory, endocrine (including uncontrolled diabetes or thyroid disease) or hematological abnormalities that are uncontrolled. Significant is defined as any disease that, in the opinion of the Investigator, would put the safety of the subject at risk through participation, or which would affect the efficacy or safety analysis if the disease/condition exacerbated during the study
- • Unstable liver disease as defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminaemia, esophageal or gastric varices or persistent jaundice, cirrhosis, known biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
- • Note: Chronic stable hepatitis B and C are acceptable if the subject otherwise meets entry criteria
- • Unstable or life threatening cardiac disease: subjects with any of the following at Screening (Visit 1) would be excluded: Myocardial infarction or unstable angina in the last 6 months; Unstable or life threatening cardiac arrhythmia requiring intervention in the last 3 months; New York Heart Association (NYHA) Class IV Heart failure
- • Abnormal and clinically significant 12-Lead Electrocardiogram (ECG) finding: Investigators will be provided with ECG reviews conducted by a centralized independent cardiologist to assist in evaluation of subject eligibility. The Principal Investigator will determine the clinical significance of each abnormal ECG finding in relation to the subject's medical history and exclude subjects who would be at undue risk by participating in the trial. An abnormal and clinically significant finding that would preclude a subject from entering the trial is defined as a 12-lead tracing that is interpreted as, but not limited to, any of the following: atrial fibrillation (AF) with rapid ventricular rate \>120 beats per minute); sustained or nonsustained ventricular tachycardia (VT); Second degree heart block Mobitz type II and third degree heart block (unless pacemaker or defibrillator had been inserted); QT interval corrected for heart rate (QTcF) \>=500 milliseconds (msec) in patients with QRS \<120 msec and QTcF \>=530 msec in patients with QRS \>=120 msec
- • Contraindications: A history of allergy or hypersensitivity to any corticosteroid, anticholinergic/muscarinic receptor antagonist, beta2-agonist, lactose/milk protein or magnesium stearate or a medical condition such as narrow-angle glaucoma, prostatic hypertrophy or bladder neck obstruction that, in the opinion of the Investigator contraindicates study participation
- • Cancer: Subjects with carcinoma that has not been in complete remission for at least 5 years. Subjects who have had carcinoma in situ of the cervix, squamous cell carcinoma and basal cell carcinoma of the skin would not be excluded based on the 5 year waiting period if the subject has been considered cured by treatment
- • Oxygen therapy: Use of long-term oxygen therapy (LTOT) described as resting oxygen therapy \>3 Liter/minute (L/min) (Oxygen use =\<3L/min flow is not exclusionary)
- • Medication prior to spirometry: Subjects who are medically unable to withhold their albuterol/salbutamol for the 4-hour period required prior to spirometry testing at each study visit
- • Pulmonary rehabilitation: Subjects who have participated in the acute phase of a Pulmonary Rehabilitation Program within 4 weeks prior to Screening or subjects who plan to enter the acute phase of a Pulmonary Rehabilitation Program during the study. Subjects who are in the maintenance phase of a Pulmonary Rehabilitation Program are not excluded
- • Drug/alcohol abuse: Subjects with a known or suspected history of alcohol or drug abuse within the last 2 years
- • Non-compliance: Subjects at risk of non-compliance, or unable to comply with the study procedures. Any infirmity, disability, or geographic location that would limit compliance for scheduled visits
- • Questionable validity of consent: Subjects with a history of psychiatric disease, intellectual deficiency, poor motivation or other conditions that will limit the validity of informed consent to participate in the study
- • Affiliation with investigator site: Study investigators, sub-investigators, study coordinators, employees of a participating investigator or study site, or immediate family members of the aforementioned that is involved with this study
- • Inability to read: In the opinion of the Investigator, any subject who is unable to read and/or would not be able to complete study related materials
- • Medication prior to screening: Use of the following medications within the following time intervals prior to Screening (Visit 1) or during the study: Long term antibiotic therapy Subjects receiving antibiotics for long term therapy are not eligible for the study (Antibiotics are allowed for the short term treatment of an exacerbation or for short term treatment of other acute infections during the study); Systemic, Oral, parenteral corticosteroids 30 days (Except during the study oral/systemic corticosteroids may be used to treat COPD exacerbations/pneumonia) Intra-articular injections are allowed; Any other investigational drug (30 days or 5 half lives whichever is longer)
About Glaxosmithkline
GlaxoSmithKline (GSK) is a global healthcare company dedicated to improving the quality of human life by enabling people to do more, feel better, and live longer. With a strong focus on research and development, GSK specializes in pharmaceuticals, vaccines, and consumer health products. The company is committed to advancing innovative therapies and preventive measures across various therapeutic areas, including respiratory, oncology, immunology, and infectious diseases. GSK's collaborative approach and rigorous clinical trial processes underscore its dedication to delivering safe and effective healthcare solutions that meet the needs of patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Decatur, Georgia, United States
New Orleans, Louisiana, United States
Bronx, New York, United States
Fort Worth, Texas, United States
Barcelona, , Spain
Sevilla, , Spain
Shreveport, Louisiana, United States
Saint Louis, Missouri, United States
Syracuse, New York, United States
Houston, Texas, United States
Asheville, North Carolina, United States
Charlotte, North Carolina, United States
Canton, Ohio, United States
Spartanburg, South Carolina, United States
Tacoma, Washington, United States
Valparaiso, Valparaíso, Chile
Hampton, Virginia, United States
Durham, North Carolina, United States
Adelaide, South Australia, Australia
Gauting, Bayern, Germany
Ramat Gan, , Israel
Leeuwarden, , Netherlands
Quezon City, , Philippines
Pittsburgh, Pennsylvania, United States
Marietta, Georgia, United States
Albany, New York, United States
Philadelphia, Pennsylvania, United States
Lynchburg, Virginia, United States
Santa Ana, California, United States
Mobile, Alabama, United States
Santa Monica, California, United States
Torrance, California, United States
Upland, California, United States
New Port Richey, Florida, United States
Woodstock, Georgia, United States
Coeur D'alene, Idaho, United States
Evansville, Indiana, United States
Ann Arbor, Michigan, United States
Edina, Minnesota, United States
Rochester, Minnesota, United States
Jackson, Mississippi, United States
Omaha, Nebraska, United States
Las Vegas, Nevada, United States
Marlton, New Jersey, United States
Greensboro, North Carolina, United States
Winston Salem, North Carolina, United States
Marion, Ohio, United States
Virginia Beach, Virginia, United States
Seattle, Washington, United States
Rosario, Santa Fe, Argentina
Westmead, New South Wales, Australia
Gent, , Belgium
Hasselt, , Belgium
Turnhout, , Belgium
Burlington, Ontario, Canada
Turku, , Finland
Nimes, , France
Dachau, Bayern, Germany
Nuernberg, Bayern, Germany
Rosenheim, Bayern, Germany
Koblenz, Rheinland Pfalz, Germany
Hettstedt, Sachsen Anhalt, Germany
Leipzig, Sachsen, Germany
Schleswig, Schleswig Holstein, Germany
Eindhoven, , Netherlands
Harderwijk, , Netherlands
Nieuwegein, , Netherlands
Ponce, , Puerto Rico
Madrid, , Spain
Oviedo, , Spain
Pamplona, , Spain
San Juan De Alicante, , Spain
Valladolid, , Spain
Exeter, Devon, United Kingdom
Albuquerque, New Mexico, United States
Maitland, Florida, United States
Iowa City, Iowa, United States
Truro, Nova Scotia, Canada
Footscray, Victoria, Australia
Glendale, Arizona, United States
Encinitas, California, United States
Golden, Colorado, United States
O'fallon, Illinois, United States
Renton, Washington, United States
Sarasota, Florida, United States
Bangor, Maine, United States
Augsburg, Bayern, Germany
Moorestown, New Jersey, United States
Elk Grove Village, Illinois, United States
Leesburg, Florida, United States
East Providence, Rhode Island, United States
Deland, Florida, United States
Lafayette, Louisiana, United States
Chesterfield, Missouri, United States
Gastonia, North Carolina, United States
Wilmington, North Carolina, United States
Anderson, South Carolina, United States
Johnson City, Tennessee, United States
Tucson, Arizona, United States
Chula Vista, California, United States
Newport Beach, California, United States
Colorado Springs, Colorado, United States
Austell, Georgia, United States
Cincinnati, Ohio, United States
Medford, Oregon, United States
Wyomissing, Pennsylvania, United States
Greenville, South Carolina, United States
Tomball, Texas, United States
Phoenix, Arizona, United States
Riverside, California, United States
Brandon, Florida, United States
Pensacola, Florida, United States
Tampa, Florida, United States
Topeka, Kansas, United States
Dayton, Ohio, United States
Kingwood, Texas, United States
Bellingham, Washington, United States
Jacksonville, Florida, United States
Downingtown, Pennsylvania, United States
Vienna, , Austria
Mannheim, Baden Wuerttemberg, Germany
Wallerfing, Bayern, Germany
Potsdam, Brandenburg, Germany
Koeln, Nordrhein Westfalen, Germany
Halberstadt, Sachsen Anhalt, Germany
Sabadell (Barcelona), , Spain
Jasper, Alabama, United States
Nedlands, Western Australia, Australia
Brugge, , Belgium
Zaragoza, , Spain
Bakersfield, California, United States
Fort Lauderdale, Florida, United States
Liège, , Belgium
Stamford, Connecticut, United States
Waterbury, Connecticut, United States
Bay Pines, Florida, United States
Chicago, Illinois, United States
Oak Park, Illinois, United States
Butte, Montana, United States
Corvallis, Oregon, United States
Genk, , Belgium
Winnipeg, Manitoba, Canada
Praha 5, , Czechia
Tampere, , Finland
Montpellier Cedex 5, , France
Pokfulam, , Hong Kong
Shatin, , Hong Kong
Afula, , Israel
Zrifin, , Israel
San Juan, , Puerto Rico
Ekaterinburg, , Russian Federation
La Coruña, , Spain
Bangkok, , Thailand
Chiangmai, , Thailand
Modesto, California, United States
Sacramento, California, United States
Winfield, Illinois, United States
Aalborg, , Denmark
Orléans Cedex 2, , France
Neu Ulm, Bayern, Germany
Holon, , Israel
Alkmaar, , Netherlands
Hoofddorp, , Netherlands
Veldhoven, , Netherlands
Santiago De Compostela, , Spain
Vizcaya, , Spain
Izmir, , Turkey
Northwood, Middlesex, United Kingdom
New Haven, Connecticut, United States
Huntersville, North Carolina, United States
Windsor, Ontario, Canada
Chattanooga, Tennessee, United States
San Antonio, Texas, United States
Concord, New South Wales, Australia
Göteborg, , Sweden
Worcester, Massachusetts, United States
Daw Park, South Australia, Australia
Vandoeuvre Les Nancy, , France
Kwun Tong, , Hong Kong
La Plata, Buenos Aires, Argentina
Novosibirsk, , Russian Federation
Khon Kaen, , Thailand
Muscle Shoals, Alabama, United States
Hartford, Connecticut, United States
Columbus, Georgia, United States
Sunset, Louisiana, United States
Elizabeth City, North Carolina, United States
Charleston, South Carolina, United States
Richmond, Virginia, United States
Huntington Beach, California, United States
Long Beach, California, United States
North Dartmouth, Massachusetts, United States
Corsicana, Texas, United States
Kerrville, Texas, United States
Vista, California, United States
Minneapolis, Minnesota, United States
Missoula, Montana, United States
Bronxville, New York, United States
Erie, Pennsylvania, United States
Gaffney, South Carolina, United States
Muncie, Indiana, United States
Seoul, , Korea, Republic Of
Girona, , Spain
Columbia, Maryland, United States
Doylestown, Pennsylvania, United States
Arcadia, California, United States
Nueve De Julio, Buenos Aires, Argentina
Santa Fe, , Argentina
Pessac Cedex, , France
Gatineau, Quebec, Canada
Mirabel, Quebec, Canada
Trebic, , Czechia
Deggingen, Baden Wuerttemberg, Germany
Mainz, Rheinland Pfalz, Germany
Birmingham, Alabama, United States
Danbury, Connecticut, United States
Port Orange, Florida, United States
Fall River, Massachusetts, United States
Ciudad Autónoma De Buenos Aires, , Argentina
Odense C, , Denmark
Muenchen, Bayern, Germany
Saarbruecken, Saarland, Germany
Delitzsch, Sachsen, Germany
Levanger, , Norway
Saratov, , Russian Federation
Yaroslavl, , Russian Federation
Durban, , South Africa
Mérida (Badajoz), , Spain
Kharkiv, , Ukraine
Olathe, Kansas, United States
Abingdon, Virginia, United States
Trois Rivieres, Quebec, Canada
Breda, , Netherlands
Tabor, , Czechia
Geesthacht, Schleswig Holstein, Germany
Mount Pleasant, South Carolina, United States
Plzen, , Czechia
Clearwater, Florida, United States
Jyvaskyla, , Finland
Berlin, , Germany
L'hospitalet De Llobregat, , Spain
Hamilton, Ontario, Canada
Frankfurt, Hessen, Germany
Gelsenkirchen, Nordrhein Westfalen, Germany
Songkla, , Thailand
Mendoza, , Argentina
Loxahatchee Groves, Florida, United States
Nanning, Guangxi, China
Dordrecht, , Netherlands
Helmond, , Netherlands
Hellerup, , Denmark
Bogota, , Colombia
Paris, , France
Tustin, California, United States
Everett, Washington, United States
Carina Heights, Queensland, Australia
Sudbury, Ontario, Canada
Rolling Hills Estates, California, United States
Hoorn, , Netherlands
Zwolle, , Netherlands
Pembroke Pines, Florida, United States
Katy, Texas, United States
Fridley, Minnesota, United States
Bucharest, , Romania
Assen, , Netherlands
Plano, Texas, United States
Stockholm, , Sweden
Santander, , Spain
Spijkenisse, , Netherlands
Clayton, Victoria, Australia
Geelong, Victoria, Australia
Tel Aviv, , Israel
Rehovot, , Israel
Jinan, Shandong, China
Tuen Mun, , Hong Kong
Hvidovre, , Denmark
Saint Charles, Missouri, United States
Bad Woerrishofen, Bayern, Germany
Landsberg, Bayern, Germany
Ruedersdorf, Brandenburg, Germany
Bonn, Nordrhein Westfalen, Germany
Dueren, Nordrhein Westfalen, Germany
Rotterdam, , Netherlands
San Diego, California, United States
Frankston, Victoria, Australia
Oostende, , Belgium
Chongqing, , China
Shanghai, , China
Helsinki, , Finland
Lohja, , Finland
Hannover, Niedersachsen, Germany
Lai Chi Kok, , Hong Kong
Mowbray, , South Africa
Kiev, , Ukraine
Brest Cedex, , France
Gillespie, Illinois, United States
Sarnia, Ontario, Canada
Le Mans, , France
Aschaffenburg, Bayern, Germany
Offenbach, Hessen, Germany
Warendorf, Nordrhein Westfalen, Germany
Basurto/Bilbao, , Spain
Sagunto/Valencia, , Spain
Troy, Michigan, United States
Tabor City, North Carolina, United States
Kassel, Hessen, Germany
Neuss, Nordrhein Westfalen, Germany
Bradford, , United Kingdom
Lewisville, Texas, United States
Sheffield, Alabama, United States
Chengdu, Sichuan, China
Bloemfontein, , South Africa
Fredrikstad, , Norway
Valencia, , Spain
Leipzg, Sachsen, Germany
Longview, Texas, United States
Sugar Land, Texas, United States
Jerusalem, , Israel
Toulon, , France
Wiesloch, Baden Wuerttemberg, Germany
Puente Alto Santiago, Región Metro De Santiago, Chile
Aichi, , Japan
Burgos, , Spain
Xian, Shanxi, China
Tianjin, , China
Krasnoyarsk, , Russian Federation
Sioux Falls, South Dakota, United States
Neuwied, Rheinland Pfalz, Germany
Gainesville, Florida, United States
Marburg, Hessen, Germany
Luleå, , Sweden
Mission Hills, California, United States
Cottbus, Brandenburg, Germany
Port Charlotte, Florida, United States
Southfield, Michigan, United States
Pittsfield, Massachusetts, United States
Panorama, , South Africa
Rio De Janeiro, , Brazil
Roskilde, , Denmark
Witten, Nordrhein Westfalen, Germany
Ashkelon, , Israel
Haifa, , Israel
Cáceres, , Spain
Antwerpen, , Belgium
Kolding, , Denmark
Kansas City, Missouri, United States
Wellington, , New Zealand
Paducah, Kentucky, United States
Rennes Cedex 9, , France
Woodbury, Minnesota, United States
Amanzimtoti, , South Africa
Bellville, , South Africa
Portland, Oregon, United States
Tygerberg, , South Africa
Ruesselsheim, Hessen, Germany
Perpignan, , France
Dortmund, Nordrhein Westfalen, Germany
Fuzhou, , China
Fremont, Nebraska, United States
Mooresville, North Carolina, United States
Barnaul, , Russian Federation
Voronezh, , Russian Federation
Gilly, , Belgium
Palo Alto, California, United States
Grand Island, Nebraska, United States
Málaga, , Spain
San Sebastian De Los Reyes, , Spain
Tomsk, , Russian Federation
Rodgau, Hessen, Germany
Hamburg, , Germany
Oviedo, Florida, United States
Toledo, Ohio, United States
Nanjing, Jiangsu, China
Schmoelln, Thueringen, Germany
Cairns, Queensland, Australia
Daytona Beach, Florida, United States
Rapid City, South Dakota, United States
Wishaw, Lanarkshire, United Kingdom
Boulder, Colorado, United States
Florence, Alabama, United States
Union, South Carolina, United States
Vicente Lopez, Buenos Aires, Argentina
Bialystok, , Poland
Brussels, , Belgium
Mar Del Plata, Buenos Aires, Argentina
Solingen, Nordrhein Westfalen, Germany
Salamanca, , Spain
Barranquilla, , Colombia
Medellin, , Colombia
Grenoble Cedex 9, , France
Kanagawa, , Japan
Stavanger, , Norway
Sopot, , Poland
Hradec Kralove, , Czechia
Ponte Vedra Beach, Florida, United States
Conyers, Georgia, United States
Franklin, Indiana, United States
Greenfield, Indiana, United States
Middleburg Heights, Ohio, United States
Gosford, New South Wales, Australia
Roeselaere, , Belgium
Guangzhou, Guangdong, China
Strasbourg Cedex, , France
Enschede, , Netherlands
Paarl, , South Africa
Pozuelo De Alarcón/Madrid, , Spain
östersund, , Sweden
Odesa, , Ukraine
Kyoto, , Japan
Calabash, North Carolina, United States
Shelby, North Carolina, United States
Tipton, Pennsylvania, United States
Lima, , Peru
Edgewater, Florida, United States
Fort Mitchell, Kentucky, United States
Alzira/Valencia, , Spain
Pringy Cedex, , France
Zerbst, Sachsen Anhalt, Germany
Bodø, , Norway
Kløfta, , Norway
Kazan, , Russian Federation
Bayonne Cedex, , France
Easley, South Carolina, United States
Seneca, South Carolina, United States
Lyon Cedex 04, , France
örebro, , Sweden
Aarhus C, , Denmark
Ostrava Poruba, , Czechia
Ibaraki, , Japan
Nagano, , Japan
Talcahuano, , Chile
Zgierz, , Poland
Saint Petersburg, , Russian Federation
Mykolayiv, , Ukraine
Shijiazhuang, Hebei, China
Shenyang, Liaoning, China
Beijing, , China
Hyogo, , Japan
Kangwon Do, , Korea, Republic Of
Groningen, , Netherlands
Sneek, , Netherlands
San Martin De Porres, Lima, Peru
Nakhon Ratchasima, , Thailand
Peoria, Arizona, United States
Quebec, , Canada
Boksburg North, , South Africa
High Heaton, Newcastle Upon Tyne, Tyne & Wear, United Kingdom
Middelburg, Mpumalanga, South Africa
Council Bluffs, Iowa, United States
Lincoln, Nebraska, United States
Beek, , Netherlands
Zutphen, , Netherlands
San Miguel, Lima, Peru
Gatesville, , South Africa
Bradford On Avon, Wiltshire, United Kingdom
Cambridge, , United Kingdom
Benesov, , Czechia
Petrer/Alicante, , Spain
Reinfeld, Schleswig Holstein, Germany
Pyatigorsk, , Russian Federation
San Miguel De Tucumán, , Argentina
Praha 8, , Czechia
Ehime, , Japan
Osaka, , Japan
Szczecin, , Poland
Constanta, , Romania
Ivanovo, , Russian Federation
Fukuoka, , Japan
Blagoveshchensk, , Russian Federation
Volgodonsk, , Russian Federation
Wichita, Kansas, United States
Fort Mill, South Carolina, United States
Bahía Blanca, Buenos Aires, Argentina
Concepcion Del Uruguay, Entre Ríos, Argentina
Buenos Aires, , Argentina
Ankara, , Turkey
Ishikawa, , Japan
Tokyo, , Japan
Kyiv, , Ukraine
Maroubra, New South Wales, Australia
La Roca Del Valles (Barcelona), , Spain
Peralada( Girona), , Spain
Borås, , Sweden
Hokkaido, , Japan
Miyagi, , Japan
Oita, , Japan
Okayama, , Japan
Yamanashi, , Japan
Gera, Thueringen, Germany
Stuttgart, Baden Wuerttemberg, Germany
Belgorod, , Russian Federation
Neptune, New Jersey, United States
Escondido, California, United States
Haikou, Hainan, China
Nanchang, Jiangxi, China
Changchun, Jilin, China
Coslada, , Spain
Montauban Cedex, , France
Dillingen, Bayern, Germany
Trondheim, , Norway
Höllviken, , Sweden
Phoenixville, Pennsylvania, United States
Olomouc, , Czechia
Teplice, , Czechia
Kumamoto, , Japan
Benoni, Gauteng, South Africa
Athens, Alabama, United States
Flagstaff, Arizona, United States
Fort Collins, Colorado, United States
Celebration, Florida, United States
Miami, Florida, United States
Orlando, Florida, United States
Saint Petersburg, Florida, United States
Rincon, Georgia, United States
Quincy, Illinois, United States
Saint Paul, Minnesota, United States
New York, New York, United States
Wooster, Ohio, United States
Rock Hill, South Carolina, United States
Edinburg, Texas, United States
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Cordoba, Córdova, Argentina
Coronel Suarez, , Argentina
Monte Grande, , Argentina
Salta, , Argentina
Feldbach, , Austria
Feldkirch, , Austria
Grieskirchen, , Austria
Thalheim Bei Wels, , Austria
Erpent, , Belgium
Zhanjiang, Guangdong, China
Yinchuan, Ningxia, China
Taiyuan, Shanxi, China
Wuxi, , China
Bogotá, , Colombia
Holesov, , Czechia
Jaromer, , Czechia
Bensheim, Hessen, Germany
Wardenburg, Niedersachsen, Germany
Bergisch Gladbach, Nordrhein Westfalen, Germany
Hagen, Nordrhein Westfalen, Germany
Gifu, , Japan
Gyeonggi Do, , Korea, Republic Of
Incheon, , Korea, Republic Of
Iloilo, , Philippines
Jaro, Iloilo City, , Philippines
Pasig, , Philippines
Ostrowiec Swietokrzyski, , Poland
Brasov, , Romania
Ploiesti, , Romania
Ramnicu Valcea, , Romania
Moscow, , Russian Federation
Ryazan, , Russian Federation
St. Petersburg, , Russian Federation
Ulyanovsk, , Russian Federation
Boksburg, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Capetown, , South Africa
Korsten, , South Africa
Mataró, , Spain
Muang, , Thailand
Istanbul, , Turkey
Sumy, , Ukraine
Sidcup, Kent, , United Kingdom
Ha Noi, , Vietnam
Ho Chi Minh, , Vietnam
Novgorod, , Russian Federation
Bamberg, Bayern, Germany
Chita, , Russian Federation
Petrozavodsk, , Russian Federation
Petah Tikva, , Israel
Ponferrada (León), , Spain
Duluth, Georgia, United States
Nan, , Thailand
Changsha, , China
Teuchern, Sachsen Anhalt, Germany
Mechelen, , Belgium
Centelles (Barcelona), , Spain
Sealy, Texas, United States
Bad Lippspringe, Nordrhein Westfalen, Germany
San Miguel De Tucuman, Tucumán, Argentina
Montigny Le Tilleul, , Belgium
Rathenow, Brandenburg, Germany
Frankenberg, Hessen, Germany
Ratingen, Nordrhein Westfalen, Germany
Auerbach, Sachsen, Germany
Lleida, , Spain
Qingdao, Shandong, China
Rheine, Nordrhein Westfalen, Germany
Kloosterhaar, , Netherlands
Neu Isenburg, Hessen, Germany
Berazategui, , Argentina
St Charles Borromée, Quebec, Canada
Jeonju Si, , Korea, Republic Of
Alicante, , Spain
Liverpool, , Australia
San Rafael, Mendoza, Argentina
Hangzhou, Zhejiang, China
Braila, , Romania
Vladivostok, , Russian Federation
Kagawa, , Japan
Concepción, Región Del Biobio, Chile
Viña Del Mar, Valparaíso, Chile
Krasnodar, , Russian Federation
Cvikov, , Czechia
Edmonton, Alberta, Canada
Kfar Saba, , Israel
Comuna Alexandru Cel Bun, , Romania
Vladimir, , Russian Federation
Hollywood, Florida, United States
Spokane Valley, Washington, United States
Sherwood Park, Alberta, Canada
Santiago, Región Metro De Santiago, Chile
Palma De Mallorca, , Spain
Boynton Beach, Florida, United States
Adairsville, Georgia, United States
Hiroshima, , Japan
Okinawa, , Japan
Bucheon City, Gyenggi Do, , Korea, Republic Of
Den Bosch, , Netherlands
Chiba, , Japan
Gunma, , Japan
Kochi, , Japan
Saitama, , Japan
Toyama, , Japan
Stavropol, , Russian Federation
Chandler, Arizona, United States
Reseda, California, United States
West Haven, Connecticut, United States
Fort Myers, Florida, United States
Hines, Illinois, United States
Louisville, Kentucky, United States
Crowley, Louisiana, United States
Reno, Nevada, United States
Hendersonville, North Carolina, United States
Lexington, North Carolina, United States
Whiteville, North Carolina, United States
Johnstown, Pennsylvania, United States
Gonzales, Texas, United States
Caba, Buenos Aires, Argentina
Florida, Buenos Aires, Argentina
Paraná, Buenos Aires, Argentina
Berazategui, Buenos Aires, , Argentina
Capital Federal, , Argentina
Ciudad Autonoma De Buenis Aires, , Argentina
Santa Rosa, , Argentina
Hamilton, Victoria, Australia
Murdoch, Western Australia, Australia
Malmedy, , Belgium
Recife, Pernambuco, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Blumenau, Santa Catarina, Brazil
Florianopolis, Santa Catarina, Brazil
São Paulo, , Brazil
Moncton, New Brunswick, Canada
Cornwall, Ontario, Canada
Toronto, Ontario, Canada
Montréal, Quebec, Canada
Curicó, Región Del Maule, Chile
Talca, Región Del Maule, Chile
Brandys Nad Labem, , Czechia
Sønderborg, , Denmark
Espoo, , Finland
Briis Sous Forge, , France
Marseille Cedex 03, , France
Leonberg, Baden Wuerttemberg, Germany
Donaustauf, Bayern, Germany
Garmisch Partenirchen, Bayern, Germany
Fuldatal, Hessen, Germany
Fulda, Hessen, Germany
Peine, Niedersachsen, Germany
Duisburg, Nordrhein Westfalen, Germany
Essen, Nordrhein Westfalen, Germany
Freudenberg, Nordrhein Westfalen, Germany
Gummersbach, Nordrhein Westfalen, Germany
Kleve, Nordrhein Westfalen, Germany
Bernkastel Kues, Rheinland Pfalz, Germany
Wissen, Rheinland Pfalz, Germany
Halle, Sachsen Anhalt, Germany
Luebeck, Schleswig Holstein, Germany
Saalfeld, Thueringen, Germany
Deggendorf, , Germany
Tel Aviv, , Israel
Iwate, , Japan
Mie, , Japan
Niigata, , Japan
Shizuoka, , Japan
Tochigi, , Japan
Wakayama, , Japan
Yamagata, , Japan
Cheongju Si, Chungcheongbuk Do, , Korea, Republic Of
Suwon, , Korea, Republic Of
Almelo, , Netherlands
Auckland, , New Zealand
Dunedin, , New Zealand
Newtown, Wellington, , New Zealand
Tauranga, , New Zealand
Hakadal, , Norway
Oslo, , Norway
Pueblo Libre, Lima, Peru
Caloocan City, , Philippines
Tarnów, , Poland
Guaynabo, , Puerto Rico
Mayaguez, , Puerto Rico
Ulan Ude, , Russian Federation
Vsevolozhsk, Leningrad Region, , Russian Federation
Singapore, , Singapore
Val De Grace, Pretoria, Gauteng, South Africa
Cape Town, , South Africa
Johannesburg, , South Africa
Marbella Málaga, Andalucia, Spain
Laredo, Cantabria, Spain
Torrelavega, Cantabria, Spain
Badalona, Catalonia, Spain
(Badalona) Barcelona, , Spain
(Barakaldo) Vizcaya, , Spain
Gerona, , Spain
Tarragona, , Spain
Linköping, , Sweden
Uppsala, , Sweden
Mersin, , Turkey
Vinnytsia, , Ukraine
Blackpool, Lancashire, United Kingdom
Baillieston, Glasgow, , United Kingdom
Chester, , United Kingdom
Crawley, , United Kingdom
Crownhill, Plymouth, , United Kingdom
Dundee, Scotland, , United Kingdom
Stockton On Tees, , United Kingdom
Trowbridge, , United Kingdom
Patients applied
Trial Officials
GSK Clinical Trials
Study Director
GlaxoSmithKline
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials