Testing Two Different Treatment Schedules of Dabrafenib and Trametinib for Skin Cancer Which Has Spread
Launched by NATIONAL CANCER INSTITUTE (NCI) · Jul 18, 2014
Trial Information
Current as of May 29, 2025
Active, not recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the effectiveness of two medications, dabrafenib and trametinib, in treating patients with advanced melanoma (skin cancer) that cannot be surgically removed, specifically those with a specific genetic mutation known as BRAF. The trial aims to see if these medications can help slow down or stop the growth of tumors in individuals with stage III or stage IV melanoma. If you or a loved one has been diagnosed with this type of cancer and has the BRAF V600E or BRAF V600K mutation, you might be eligible to participate.
To join the trial, participants need to be at least 18 years old and must have a confirmed diagnosis of melanoma with the specific BRAF mutation. They should not have received certain prior cancer treatments and must meet specific health criteria, such as having adequate blood counts and no significant heart or liver issues. If eligible, participants will receive the study medications and be monitored for their response to treatment. This trial is currently ongoing, and while it’s not recruiting new participants right now, it’s important for those interested to discuss it with their healthcare provider for future opportunities.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • STEP 1: REGISTRATION
- • Patients must have histologically or cytologically confirmed stage IV or unresectable stage III BRAF V600E or BRAF V600K mutant melanoma
- • Patients must have BRAF V600E or BRAF V600K mutation identified by a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory; acceptable analytic techniques include but are not restricted to DNA sequencing, pyrosequencing, polymerase chain reaction (PCR), melting point assays, and immunohistochemistry
- • Contrast-enhanced CT scans of the neck, chest, abdomen and pelvis are required; a whole body PET/CT scan with diagnostic quality images and intravenous iodinated contrast may be used in lieu of a contrast enhanced CT of the neck, chest, abdomen and pelvis; contrast may be omitted if the treating investigator believes that exposure to contrast poses an excessive risk to the patient; patients must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; all measurable lesions must be assessed within 28 days prior to registration; tests to assess non-measurable disease must be performed within 42 days prior to registration; all disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1)
- • Patients must not have received a prior BRAF or MEK inhibitor
- • Patients with a history of brain metastases are eligible if the patient is asymptomatic with no residual neurological dysfunction and has not received enzyme-reducing anti-epileptic drugs or corticosteroids for at least 7 days prior to registration
- • Patients must not have received any anti-cancer drug within 28 days prior to registration, and must not have received any nitrosoureas or mitomycin C within 42 days prior to registration
- • Patients must not have received any major surgery or immunotherapy within 28 days prior to registration
- • Patients must not have any unresolved toxicity greater than National Cancer Institute (NCI)-CTCAE version (v) 4.0 grade 1 from previous anti-cancer therapy except alopecia within 7 days prior to registration
- • Patients must be age \>= 18 years of age
- • Absolute neutrophil count (ANC) \>= 1,200/ul (obtained within 28 days prior to registration)
- • Platelets \>= 100,000/ul (obtained within 28 days prior to registration)
- • Hemoglobin \>= 9 g/dL (obtained within 28 days prior to registration)
- • Total bilirubin =\< 1.5 x institutional upper limit of normal (IULN) (or =\< 2.5 x upper limit of normal \[ULN\] with Gilbert's syndrome) (obtained within 28 days prior to registration)
- • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 x IULN (or \< 5 x IULN for patients with known liver metastases) (obtained within 28 days prior to registration)
- • Serum albumin \>= 2.5 g/dL (obtained within 28 days prior to registration)
- • Serum creatinine =\< 1.5 mg/dL OR measured or calculated creatinine clearance \>= 50 mL/min; creatinine measurements must be obtained within 28 days prior to registration
- • Patients must have lactate dehydrogenase (LDH) obtained within 28 days prior to registration in order to obtain baseline stratification information
- • Patients must have a left ventricular ejection fraction (LVEF) \>= institutional lower limit of normal (ILLN) by ECHO or MUGA within 28 days prior to registration
- • Patients must have corrected QT (QTc) =\< 480 msec by electrocardiogram (ECG) (corrected using the Bazett's formula) within 28 days prior to registration
- * Patients with known history or current evidence of retinal vein occlusion (RVO) or central serous retinopathy (CSR) are not eligible:
- • History of RVO or CSR, or predisposing factors to RVO or CSR (e.g. uncontrolled glaucoma or ocular hypertension, uncontrolled systemic disease such as hypertension, diabetes mellitus, or history of hyperviscosity or hypercoagulability syndromes)
- * Visible retinal pathology as assessed by ophthalmic exam that is considered a risk factor for RVO or CSR such as:
- • Evidence of new optic disc cupping
- • Evidence of new visual field defects
- • Intraocular pressure \> 21 mmHg
- • NOTE: ophthalmic exam is required for all patients; exam must be obtained within 28 days prior to registration
- • Patients must be able to take oral medications; patients must not have any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of protocol treatment (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection)
- • Patients receiving anticoagulation treatment are allowed to participate with international normalized ratio (INR) established within the therapeutic range
- • Patients must not have a history of pneumonitis or interstitial lung disease
- • Patients must not have any grade II/III/IV cardiac disease as defined by the New York Heart Association criteria (i.e., patients with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort), unstable angina pectoris, myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia; abnormal cardiac valve morphology (\>= grade 2) documented by echocardiogram (subjects with grade 1 abnormalities \[i.e., mild regurgitation/stenosis\]) can be entered on study; patients with a history of atrial fibrillation must have atrial fibrillation controlled for at least 30 days prior to registration
- • Patients with known hepatitis B or hepatitis C are not eligible, regardless of concomitant antiretroviral therapy or current viral load
- * Patients with known human immunodeficiency virus (HIV) may be eligible providing they meet the following additional criteria:
- • Cluster of differentiation (CD)4 cells \>= 500/uL
- • Serum HIV viral load of \< 25,000 IU/ml
- • No current antiretroviral therapy
- • Tests must be obtained within 28 days prior to registration; patients who are HIV positive (+) and do not meet all of these criteria are not eligible for this study (HIV/hepatitis testing are not required for patients without known infection)
- • Pre-study history and physical must be obtained with 28 days prior to registration
- • Patients must have dermatology exam obtained within 28 days prior to registration to obtain baseline measurement; exam to be performed by treating physician or designated dermatologist
- • Patients must have Zubrod performance status of 0, 1 or 2
- • No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for three years; exception: patients with known history of colon cancer, cancer of the pancreas, or any cancer known to harbor an activating RAS mutation are ineligible regardless of stage or time since diagnosis
- • Patients must not be pregnant or nursing because of the risk of fetal harm; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures; hormonal contraception is not allowed due to drug interactions which can render hormonal contraceptives ineffective
- • Patients must be offered the opportunity to participate in specimen banking
- • Patients with cutaneous or superficial lesions that do not require imaging guidance for biopsy must be willing to undergo biopsies for tissue submission and blood draws for translational medicine
- • Patients or their legally authorized representative must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
- • As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
- • STEP 2: RANDOMIZATION
- • After completing one cycle of therapy, patients will be registered for randomization between intermittent and continuous dosing, provided that they were eligible for the initial step 1 registration and satisfy the following criteria
- • Patients must not have unequivocal disease progression (by RECIST v1.1) during the first cycle; patients must have disease assessed using the same method as baseline within +/- 5 days of the day 56 scheduled assessment (between days 51-55 of cycle 1, or days 1-5 of cycle 2); all disease must be assessed and documented on the follow-up tumor assessment form (RECIST 1.1)
- • Patients must be registered to step 2: randomization within +/- 5 days of starting cycle 2; patients MUST NOT be registered prior to the day 56 disease assessment
About National Cancer Institute (Nci)
The National Cancer Institute (NCI) is a prominent component of the National Institutes of Health (NIH), dedicated to advancing cancer research and improving patient outcomes through innovative clinical trials. As a leading sponsor of cancer-related studies, NCI focuses on facilitating the development of new therapies, enhancing prevention strategies, and understanding the biology of cancer. The institute collaborates with academic institutions, healthcare providers, and industry partners to conduct rigorous clinical trials that aim to translate scientific discoveries into effective treatments. NCI’s commitment to fostering a robust research environment supports the mission to eliminate cancer as a major health problem.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
San Leandro, California, United States
Denver, Colorado, United States
Kissimmee, Florida, United States
Savannah, Georgia, United States
'Aiea, Hawaii, United States
Roseville, Michigan, United States
Lewisburg, Pennsylvania, United States
Johnson City, Tennessee, United States
Lakewood, Washington, United States
Tacoma, Washington, United States
Cody, Wyoming, United States
Traverse City, Michigan, United States
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Dodge City, Kansas, United States
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State College, Pennsylvania, United States
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Bettendorf, Iowa, United States
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Loveland, Colorado, United States
Edina, Minnesota, United States
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Pekin, Illinois, United States
Rockford, Illinois, United States
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San Francisco, California, United States
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Clive, Iowa, United States
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Mattoon, Illinois, United States
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Atlanta, Georgia, United States
Honolulu, Hawaii, United States
Savannah, Georgia, United States
Fruitland, Idaho, United States
Honolulu, Hawaii, United States
Decatur, Illinois, United States
Effingham, Illinois, United States
Peoria, Illinois, United States
Peoria, Illinois, United States
Peru, Illinois, United States
Peru, Illinois, United States
Princeton, Illinois, United States
Springfield, Illinois, United States
Swansea, Illinois, United States
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Yorkville, Illinois, United States
Sandpoint, Idaho, United States
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Clive, Iowa, United States
Clive, Iowa, United States
Davenport, Iowa, United States
Des Moines, Iowa, United States
Des Moines, Iowa, United States
Des Moines, Iowa, United States
Sioux City, Iowa, United States
West Des Moines, Iowa, United States
El Dorado, Kansas, United States
Emporia, Kansas, United States
Parsons, Kansas, United States
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Manhattan, Kansas, United States
Pittsburg, Kansas, United States
Topeka, Kansas, United States
Louisville, Kentucky, United States
Corbin, Kentucky, United States
Belfast, Maine, United States
Crestview Hills, Kentucky, United States
Baltimore, Maryland, United States
Grand Rapids, Michigan, United States
Monroe, Michigan, United States
Muskegon, Michigan, United States
Port Huron, Michigan, United States
Port Huron, Michigan, United States
Fridley, Minnesota, United States
Willmar, Minnesota, United States
Woodbury, Minnesota, United States
Wyoming, Minnesota, United States
Minneapolis, Minnesota, United States
Pascagoula, Mississippi, United States
Jackson, Mississippi, United States
Lee's Summit, Missouri, United States
Lee's Summit, Missouri, United States
Saint Louis, Missouri, United States
Saint Louis, Missouri, United States
Springfield, Missouri, United States
Omaha, Nebraska, United States
Omaha, Nebraska, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Pahrump, Nevada, United States
Kansas City, Missouri, United States
Hackensack, New Jersey, United States
Holmdel, New Jersey, United States
Neptune, New Jersey, United States
Red Bank, New Jersey, United States
Summit, New Jersey, United States
Rochester, New York, United States
Asheville, North Carolina, United States
Asheville, North Carolina, United States
Goldsboro, North Carolina, United States
Goldsboro, North Carolina, United States
Kinston, North Carolina, United States
Matthews, North Carolina, United States
Richlands, North Carolina, United States
Huntersville, North Carolina, United States
Belpre, Ohio, United States
Jacksonville, North Carolina, United States
Centerville, Ohio, United States
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Columbus, Ohio, United States
Boardman, Ohio, United States
Dayton, Ohio, United States
Kettering, Ohio, United States
Kettering, Ohio, United States
Newark, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Newark, Ohio, United States
Oregon, Ohio, United States
Toledo, Ohio, United States
Portsmouth, Ohio, United States
Sidney, Ohio, United States
Toledo, Ohio, United States
Newberg, Oregon, United States
Chadds Ford, Pennsylvania, United States
Zanesville, Ohio, United States
Johnstown, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Wilkes Barre, Pennsylvania, United States
Williamsport, Pennsylvania, United States
Bristol, Tennessee, United States
Cedar City, Utah, United States
Salt Lake City, Utah, United States
Bellevue, Washington, United States
Bellevue, Washington, United States
Burien, Washington, United States
Centralia, Washington, United States
Gig Harbor, Washington, United States
South Jordan, Utah, United States
Lynnwood, Washington, United States
Port Townsend, Washington, United States
Spokane, Washington, United States
Kennewick, Washington, United States
Johnson Creek, Wisconsin, United States
Lacey, Washington, United States
Kenosha, Wisconsin, United States
Mukwonago, Wisconsin, United States
Marinette, Wisconsin, United States
Sheridan, Wyoming, United States
Richmond, California, United States
Denver, Colorado, United States
Sacramento, California, United States
Parker, Colorado, United States
Pueblo, Colorado, United States
Savannah, Georgia, United States
Honolulu, Hawaii, United States
Meridian, Idaho, United States
Geneva, Illinois, United States
Glenview, Illinois, United States
Madisonville, Kentucky, United States
Helena, Montana, United States
Hendersonville, North Carolina, United States
Creston, Iowa, United States
Columbus, Ohio, United States
Dayton, Ohio, United States
Matthews, North Carolina, United States
Pittsburgh, Pennsylvania, United States
Springfield, Ohio, United States
Rapid City, South Dakota, United States
Farmington, Utah, United States
Logan, Utah, United States
Milwaukee, Wisconsin, United States
Winfield, Kansas, United States
Bardstown, Kentucky, United States
Oregon City, Oregon, United States
Danville, Pennsylvania, United States
West Des Moines, Iowa, United States
Mcpherson, Kansas, United States
Pratt, Kansas, United States
Baker City, Oregon, United States
Elizabethtown, Kentucky, United States
Biddeford, Maine, United States
Reno, Nevada, United States
Lake Success, New York, United States
Delaware, Ohio, United States
Springfield, Ohio, United States
Ontario, Oregon, United States
Kingsport, Tennessee, United States
Ooltewah, Tennessee, United States
Ogden, Utah, United States
Silverdale, Washington, United States
Madison, Wisconsin, United States
Wauwatosa, Wisconsin, United States
Grand Island, Nebraska, United States
Saint Joseph, Michigan, United States
Lexington, Kentucky, United States
Kenansville, North Carolina, United States
Tucson, Arizona, United States
Aurora, Colorado, United States
Englewood, Colorado, United States
Liberty, Missouri, United States
Findlay, Ohio, United States
Chanute, Kansas, United States
Newton, Kansas, United States
Manahawkin, New Jersey, United States
Bend, Oregon, United States
Denver, Colorado, United States
Council Bluffs, Iowa, United States
Lexington, Kentucky, United States
Bryan, Texas, United States
Bozeman, Montana, United States
Great Falls, Montana, United States
Lewes, Delaware, United States
Los Angeles, California, United States
Redwood City, California, United States
Monticello, Minnesota, United States
Seattle, Washington, United States
Rolla, Missouri, United States
Dayton, Ohio, United States
Delaware, Ohio, United States
Milwaukee, Wisconsin, United States
Kansas City, Missouri, United States
Mckeesport, Pennsylvania, United States
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Milwaukee, Wisconsin, United States
Aurora, Illinois, United States
Salina, Kansas, United States
Littleton, Colorado, United States
Denver, Colorado, United States
Denver, Colorado, United States
Durango, Colorado, United States
Lafayette, Colorado, United States
Lawrence, Kansas, United States
Corbin, Kentucky, United States
Bangor, Maine, United States
Winchester, Massachusetts, United States
Longview, Washington, United States
Independence, Missouri, United States
Missoula, Montana, United States
Omaha, Nebraska, United States
Papillion, Nebraska, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Chillicothe, Ohio, United States
Warren, Ohio, United States
West Chester, Ohio, United States
Greer, South Carolina, United States
Sullivan, Missouri, United States
Sunset Hills, Missouri, United States
Murray, Utah, United States
Hixson, Tennessee, United States
Saint George, Utah, United States
Everett, Washington, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Missoula, Montana, United States
Lone Tree, Colorado, United States
Sterling Heights, Michigan, United States
Brewer, Maine, United States
Clackamas, Oregon, United States
Grand Rapids, Michigan, United States
Anchorage, Alaska, United States
Anchorage, Alaska, United States
Sedro Woolley, Washington, United States
Dublin, California, United States
Ames, Iowa, United States
Rolla, Missouri, United States
Milwaukee, Wisconsin, United States
Bonne Terre, Missouri, United States
Bristol, Virginia, United States
Saint Joseph, Missouri, United States
Marinette, Wisconsin, United States
Newburgh, Indiana, United States
Norway, Maine, United States
Richmond, Indiana, United States
Woodland Hills, California, United States
Kalispell, Montana, United States
Savannah, Georgia, United States
Johnson Creek, Wisconsin, United States
Grand Rapids, Michigan, United States
Columbia, Missouri, United States
Jacksonville, North Carolina, United States
Anchorage, Alaska, United States
Saint Louis, Missouri, United States
Highland Park, Illinois, United States
London, Kentucky, United States
Royal Oak, Michigan, United States
Troy, Michigan, United States
Davenport, Iowa, United States
Fargo, North Dakota, United States
Hutchinson, Minnesota, United States
Columbus, Ohio, United States
Dayton, Ohio, United States
Maple Grove, Minnesota, United States
Dearborn, Michigan, United States
Saint Louis, Missouri, United States
Seattle, Washington, United States
Kansas City, Missouri, United States
Springfield, Missouri, United States
Walnut Creek, California, United States
Los Angeles, California, United States
Grand Junction, Colorado, United States
Fort Lauderdale, Florida, United States
Kewanee, Illinois, United States
Honolulu, Hawaii, United States
Macomb, Illinois, United States
Fort Scott, Kansas, United States
Mishawaka, Indiana, United States
Garden City, Kansas, United States
Reed City, Michigan, United States
Wellington, Kansas, United States
Branson, Missouri, United States
Billings, Montana, United States
Wyoming, Michigan, United States
Billings, Montana, United States
Billings, Montana, United States
Las Vegas, Nevada, United States
Henderson, Nevada, United States
Charlotte, North Carolina, United States
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Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Fairfield, Ohio, United States
Pittsburgh, Pennsylvania, United States
Lawton, Oklahoma, United States
Poulsbo, Washington, United States
New Richmond, Wisconsin, United States
Charlotte, North Carolina, United States
Cincinnati, Ohio, United States
Anchorage, Alaska, United States
Los Angeles, California, United States
Columbia, Missouri, United States
Kansas City, Missouri, United States
Brick, New Jersey, United States
Charleston, South Carolina, United States
Provo, Utah, United States
Aurora, Colorado, United States
Federal Way, Washington, United States
Bozeman, Montana, United States
Issaquah, Washington, United States
Oconomowoc, Wisconsin, United States
Youngstown, Ohio, United States
Riverton, Utah, United States
Puyallup, Washington, United States
Anchorage, Alaska, United States
Anaconda, Montana, United States
Henderson, Nevada, United States
Reno, Nevada, United States
Anchorage, Alaska, United States
Walla Walla, Washington, United States
Springfield, Ohio, United States
Oklahoma City, Oklahoma, United States
Newark, Delaware, United States
Honolulu, Hawaii, United States
Lexington, Kentucky, United States
Henderson, Nevada, United States
Clinton, North Carolina, United States
Oklahoma City, Oklahoma, United States
Farmington Hills, Michigan, United States
Charlotte, North Carolina, United States
Kinston, North Carolina, United States
Dayton, Ohio, United States
Charleston, South Carolina, United States
Charleston, South Carolina, United States
Burlington, Massachusetts, United States
Sunset Hills, Missouri, United States
Las Vegas, Nevada, United States
Scranton, Pennsylvania, United States
Charleston, South Carolina, United States
Anchorage, Alaska, United States
Durango, Colorado, United States
Cincinnati, Ohio, United States
Coos Bay, Oregon, United States
Poulsbo, Washington, United States
Kearney, Nebraska, United States
Sanford, Maine, United States
Greensburg, Pennsylvania, United States
Hazleton, Pennsylvania, United States
Federal Way, Washington, United States
Bellflower, California, United States
Las Vegas, Nevada, United States
Yakima, Washington, United States
Seneca, Pennsylvania, United States
Asheville, North Carolina, United States
Selinsgrove, Pennsylvania, United States
Renton, Washington, United States
Eureka, Illinois, United States
Oshkosh, Wisconsin, United States
Racine, Wisconsin, United States
Emeryville, California, United States
Panorama City, California, United States
Rancho Cordova, California, United States
Sacramento, California, United States
Aurora, Colorado, United States
Denver, Colorado, United States
Greeley, Colorado, United States
Lafayette, Colorado, United States
Littleton, Colorado, United States
Thornton, Colorado, United States
Newark, Delaware, United States
Bloomington, Illinois, United States
Carterville, Illinois, United States
Carthage, Illinois, United States
Galesburg, Illinois, United States
Mount Vernon, Illinois, United States
O'fallon, Illinois, United States
Pekin, Illinois, United States
Pekin, Illinois, United States
Rockford, Illinois, United States
Overland Park, Kansas, United States
Overland Park, Kansas, United States
Overland Park, Kansas, United States
Salina, Kansas, United States
Farmington Hills, Michigan, United States
'Aiea, Hawaii, United States
Honolulu, Hawaii, United States
Honolulu, Hawaii, United States
Coon Rapids, Minnesota, United States
Duluth, Minnesota, United States
Duluth, Minnesota, United States
Maplewood, Minnesota, United States
Maplewood, Minnesota, United States
Minneapolis, Minnesota, United States
Kearney, Nebraska, United States
Las Vegas, Nevada, United States
Farmington Hills, Michigan, United States
Grand Rapids, Michigan, United States
Kalamazoo, Michigan, United States
Niles, Michigan, United States
Las Vegas, Nevada, United States
Morristown, New Jersey, United States
Middletown, New York, United States
Findlay, Ohio, United States
Franklin, Ohio, United States
Greenville, Ohio, United States
Portland, Oregon, United States
Charleston, South Carolina, United States
Charleston, South Carolina, United States
Auburn, Washington, United States
Las Vegas, Nevada, United States
Bainbridge Island, Washington, United States
Bellingham, Washington, United States
Las Vegas, Nevada, United States
Bremerton, Washington, United States
Modesto, California, United States
Oakland, California, United States
Aurora, Colorado, United States
Fergus Falls, Minnesota, United States
Boulder, Colorado, United States
Gaffney, South Carolina, United States
Edmonds, Washington, United States
Boulder, Colorado, United States
Honolulu, Hawaii, United States
Orlando, Florida, United States
Honolulu, Hawaii, United States
Honolulu, Hawaii, United States
Boise, Idaho, United States
Centralia, Illinois, United States
Effingham, Illinois, United States
Minneapolis, Minnesota, United States
New Ulm, Minnesota, United States
Robbinsdale, Minnesota, United States
Wright Patterson Air Force Base, Ohio, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Caldwell, Idaho, United States
Coeur D'alene, Idaho, United States
Rogers, Arkansas, United States
Anaheim, California, United States
Antioch, California, United States
Emmett, Idaho, United States
Mount Pleasant, South Carolina, United States
Spartanburg, South Carolina, United States
'Aiea, Hawaii, United States
Union, South Carolina, United States
Bristol, Tennessee, United States
Chattanooga, Tennessee, United States
Fort Smith, Arkansas, United States
Peoria, Illinois, United States
Little Rock, Arkansas, United States
Shakopee, Minnesota, United States
Stillwater, Minnesota, United States
Orlando, Florida, United States
San Diego, California, United States
San Diego, California, United States
Colorado Springs, Colorado, United States
Longmont, Colorado, United States
Wilmington, Delaware, United States
Orlando, Florida, United States
Springfield, Illinois, United States
Springfield, Illinois, United States
Huntersville, North Carolina, United States
Louisville, Kentucky, United States
Paducah, Kentucky, United States
Royal Oak, Michigan, United States
Mooresville, North Carolina, United States
Bremerton, Washington, United States
Moon, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Las Vegas, Nevada, United States
Greenville, South Carolina, United States
San Marcos, California, United States
San Rafael, California, United States
San Rafael, California, United States
Sandpoint, Idaho, United States
Las Vegas, Nevada, United States
Kingsport, Tennessee, United States
Warrenville, Illinois, United States
Augusta, Maine, United States
Evansville, Indiana, United States
Johnson Creek, Wisconsin, United States
South Portland, Maine, United States
Adrian, Michigan, United States
Kenansville, North Carolina, United States
Richlands, North Carolina, United States
Baker City, Oregon, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Uniontown, Pennsylvania, United States
Washington, Pennsylvania, United States
Miami Beach, Florida, United States
Evanston, Illinois, United States
Springfield, Illinois, United States
Saint Louis Park, Minnesota, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Troy, Ohio, United States
Troy, Ohio, United States
Ontario, Oregon, United States
West Reading, Pennsylvania, United States
Salt Lake City, Utah, United States
Anderson, South Carolina, United States
Sacramento, California, United States
Seaford, Delaware, United States
Honolulu, Hawaii, United States
Honolulu, Hawaii, United States
Riverside, California, United States
Rohnert Park, California, United States
Omaha, Nebraska, United States
Carson City, Nevada, United States
Las Vegas, Nevada, United States
Kettering, Ohio, United States
Lancaster, Ohio, United States
Silvis, Illinois, United States
Marietta, Ohio, United States
Skokie, Illinois, United States
Wichita, Kansas, United States
Wichita, Kansas, United States
Grosse Pointe, Michigan, United States
Kalamazoo, Michigan, United States
Fresno, California, United States
Saint Paul, Minnesota, United States
Henderson, Nevada, United States
Abington, Pennsylvania, United States
Salt Lake City, Utah, United States
Aberdeen, Washington, United States
Beaver, Pennsylvania, United States
Las Vegas, Nevada, United States
Winter Park, Florida, United States
Meridian, Idaho, United States
Nampa, Idaho, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Westerville, Ohio, United States
Greenville, South Carolina, United States
Anchorage, Alaska, United States
Fairbanks, Alaska, United States
Las Vegas, Nevada, United States
Newark, Delaware, United States
Las Vegas, Nevada, United States
Clinton, North Carolina, United States
Hendersonville, North Carolina, United States
Oklahoma City, Oklahoma, United States
Redmond, Oregon, United States
Waukesha, Wisconsin, United States
West Allis, Wisconsin, United States
Emeryville, California, United States
Fontana, California, United States
Omaha, Nebraska, United States
Royal Oak, Michigan, United States
Santa Clara, California, United States
Santa Rosa, California, United States
Vallejo, California, United States
Walnut Creek, California, United States
Oakland, California, United States
Oakland, California, United States
Sheboygan, Wisconsin, United States
Boise, Idaho, United States
Lewistown, Pennsylvania, United States
Saint Paul, Minnesota, United States
Waconia, Minnesota, United States
Waukesha, Wisconsin, United States
Golden, Colorado, United States
Des Moines, Iowa, United States
Shepherdsville, Kentucky, United States
Detroit, Michigan, United States
Centerville, Ohio, United States
'Aiea, Hawaii, United States
Silvis, Illinois, United States
Niles, Michigan, United States
Reed City, Michigan, United States
Charlotte, North Carolina, United States
Beavercreek, Ohio, United States
Cincinnati, Ohio, United States
Perrysburg, Ohio, United States
Clive, Iowa, United States
Davenport, Iowa, United States
Des Moines, Iowa, United States
Des Moines, Iowa, United States
Rolla, Missouri, United States
Pottsville, Pennsylvania, United States
Gig Harbor, Washington, United States
Puyallup, Washington, United States
Littleton, Colorado, United States
Parker, Colorado, United States
Springfield, Illinois, United States
Pittsburg, Kansas, United States
Winchester, Massachusetts, United States
Sacramento, California, United States
Cape Girardeau, Missouri, United States
Union, South Carolina, United States
Lincoln, Nebraska, United States
Roseville, California, United States
Liberty, Missouri, United States
Kearney, Nebraska, United States
Cheyenne, Wyoming, United States
Cody, Wyoming, United States
Patients applied
Trial Officials
Alain P Algazi
Principal Investigator
SWOG Cancer Research Network
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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