Influence of Hyaluronic Acid on Bacillus Calmette-Guérin Local Side Effects

Launched by UNIVERSITY OF ROME TOR VERGATA · Aug 1, 2014

Keywords

ClinConnect Summary

Bacillus Calmette-Guérin (BCG) is considered the most effective treatment to increase disease-free interval and reduce progression of non-muscle invasive bladder cancer (NMIBC) \[1\]. Although considered safe, BCG can produce both local and systemic side effects leading to treatment discontinuation or interruption. The most common local side-effects of BCG intravesical instillations include cystitis, characterized by irritative voiding symptoms and hematuria, which occur in approximately 75% of all patients. More rarely, serious local adverse events as a result of BCG infection, such as sym...

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Eligibility criteria

• Inclusion Criteria:
• • Histologically proven non-muscle invasive bladder cancer;
• • Indication to intravesical instillation of BCG according to EAU guidelines;
• • Age \> 18 years;
• • Willingness, to participate to the study;
• • Written informed consent.
• Exclusion Criteria:
• • Previous or ongoing BCG or different intravesical instillations;
• • Urinary tract infections (UTI) or other known pathologies of the lower urinary tract;
• • Indication for a radical cystectomy;
• • Severe systemic disorders, including neurological pathologies, kidney, liver or heart failure;
• • Contraindications to BCG use.