Use of Ibuprofen and Acetaminophen for Treatment of Acute Headache Post Concussion in Children
Launched by MCMASTER CHILDREN'S HOSPITAL · Oct 15, 2014
Trial Information
Current as of May 09, 2025
Completed
Keywords
ClinConnect Summary
Objective Post Injury concussion and headache are problematic for children after mild traumatic brain injuries. There are no evidence based guidelines for the management of acute post concussive headache. The objectives of this study were to assess the efficacy of routine administration of analgesia on concussion headache and classify headaches using the IHS criteria.
Method A 4 arm open label pilot RCT study was conducted. The treatment arms were: (i) acetaminophen,(ii) ibuprofen, (iii) acetaminophen and ibuprofen and (iv) a standard control group. Eight to eighteen year olds presenting t...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • diagnosed with a first time concussion
- • english speaking
- • presenting to Emergency with headache 24-48 hours post concussion
- • normal Glascow Coma Scale
- • 8-18 years of age
- • Exclusion Criteria
- • postive findings on CT scan
- • patient with cervical injury
- • history of multiple concussions
- • positive neurology
About Mcmaster Children's Hospital
McMaster Children’s Hospital is a leading pediatric healthcare institution dedicated to advancing child health through innovative research and clinical excellence. As a prominent sponsor of clinical trials, the hospital focuses on improving treatments and outcomes for children with various medical conditions. Leveraging its multidisciplinary expertise and state-of-the-art facilities, McMaster Children’s Hospital collaborates with academic institutions, healthcare providers, and industry partners to conduct rigorous clinical research that adheres to the highest ethical standards. Committed to fostering a culture of inquiry and discovery, the hospital aims to translate research findings into practical applications that enhance the quality of care for pediatric patients.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
Tina m Petrelli, PhD
Principal Investigator
McMaster Children's Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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