Local Uterine Application of Low Molecular Weight Heparin (LMWH) in Intra-cytoplasmic Sperm Injection (ICSI)

Launched by THE EGYPTIAN IVF-ET CENTER · Dec 21, 2014

Keywords

ClinConnect Summary

Following ethical approval of the committee of Egyptian IVF-ET center, a pilot prospective randomized controlled study will include 40 patients, in which the study arm (group A ) will be injected with LMWH intrauterine during mock embryo transfer, just after ovum pickup, while the control arm (group B) will be injected intrauterine with similar volume tissue culture media (G.2 plus ref. 10132, Vitrolife) also after ovum pickup. Admission into either group will be through randomization after inclusion \& exclusion criteria have been met and before start of controlled ovarian stimulation prot...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Normal serum prolactin level \& thyroid stimulating hormone (TSH)
• • 2. Unexplained infertility
• • 3. Tubal factor infertility
• • 4. BMI \<30 kg/m2
• Exclusion Criteria:
• • 1. Reduced ovarian reserve by AFC, Anti-mullerian hormone (AMH)
• • 2. Presence of non disconnected hydrosalpinges
• • 3. Frozen embryo transfer cycles
• • 4. Uterine Anomalies
• • 5. Submucous fibroids and polyps
• • 6. Uterine synechia
• • 7. Contraindication of pregnancy e.g.: Somatic and mental diseases, which are contraindications for carrying of a pregnancy and childbirth, inborn malformations or acquired deformations of uterus cavity which make embryo implantation or carrying of a pregnancy impossible ,ovarian tumors