Eating Behaviour in Crohn's Disease

Launched by UNIVERSITY OF NOTTINGHAM · Feb 26, 2015

Keywords

ClinConnect Summary

STUDY BACKGROUND INFORMATION AND RATIONALE

Crohn's disease (CD) patients can present with a variety of luminal and extra-luminal symptoms but nutritional abnormalities are a very common but poorly studied \[1\] problem in this disease \[2\]. Apart from disease burden and repeated surgery, reduced appetite \[3\] and associated symptoms such as nausea undoubtedly contribute, with a major impact on quality of life.

Appetite and satiation, the processes by which a meal is terminated, involve complex interactions of homeostatic and hedonic factors. While the hypothalamus is central in the home...

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Eligibility criteria

• Inclusion Criteria:
• • -
• We will study a cohort of CD patients with active disease as defined by:
• • 1. Age 16-75 years
• • 2. Ulceration seen at ileocolonoscopy, aiming for a simple endoscopic score for Crohn's disease (SES-CD) of 4-19, in the absence of stricturing disease or,
• • 3. Intestinal inflammation or deep ulceration seen on CT or MR enterography, with the disease activity quantified via the MaRIA score or
• • 4. Faecal calprotectin of \>250µg/g or
• • 5. C-Reactive protein \>5mg/dl or,
• • 6. Harvey-Bradshaw index score of 5-16
• • 7. Body mass index (BMI) of 18-30.
• • For HV participants, inclusion criteria's 1 and 7 apply.
• Exclusion Criteria:
• • 1. Present or recent (within 12 weeks) corticosteroid usage
• • 2. Malignant disease
• • 3. BMI \<18 or \>30.
• • 4. Significant cardiovascular or respiratory disease
• • 5. Diabetes mellitus
• • 6. Current Infection
• • 7. Neurological or cognitive impairment; significant physical disability
• • 8. Significant hepatic disease or renal failure
• • 9. Abnormal blood results other than those explained by CD including bleeding diatheses (apart from in the case of HV where all unexplained blood results are an exclusion criteria) ,
• • 10. Subjects currently participating in (or in the last three months) any other research project
• • 11. pregnancy or breastfeeding or
• • 12. Severe CD where a delay in a change in medical treatment for 1 weeks would not be clinically advisable
• • For HV participants, all exclusion criteria apply with the exception of criteria no.12