Confocal Fluorescence Microscopy of the Human Airways in Diagnostics of Lung Transplantation

Launched by BOSTON CHILDREN'S HOSPITAL · Mar 17, 2015

Keywords

ClinConnect Summary

Bronchoscopy-guided tissue sampling is a central technique in many diseases including diagnosing and staging lung cancers, diagnosing interstitial lung diseases, and acute and/or chronic rejections following lung transplantation. Confocal fluorescence microscopy is a novel technique used for in vivo microscopic imaging of proximal and distal airways including bronchial and alveolar walls, microvessels, and inflammatory cells. We hypothesize that confocal fluorescence microscopy images of bronchiolar and alveolar structures during standard bronchoscopy could help recognize and classify the p...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • to be older than six years of age
• • to be undergoing surveillance or clinically indicated bronchoscopies with transbronchial biopsy as part of their routine care
• • to be willing and able to comply with study procedures and provide written informed consent/assent to participate in the study
• Exclusion Criteria:
• • to be unwilling to consent
• • to be unable to safely tolerate a bronchoscopic procedure
• • to have any contraindications to short-acting anesthetic agents
• • to have any contraindications to transbronchial biopsies