Oxidative Damage and Antioxidant Mechanisms in COPD

Launched by YUZUNCU YIL UNIVERSITY · Mar 27, 2015

Keywords

ClinConnect Summary

Introduction Lung is a particularly important organ because of its interface with the environment. The environmental pollutants and endogenous reactive oxygen metabolites from inflammatory cells exert substantial pathological effects on the lung cells \[1\]. Oxidative stress (OS) is a major factor that plays a significant role in lung cancer (LC) \[2\], chronic obstructive pulmonary disease (COPD) \[3\] and obstructive sleep apnea syndrome (OSAS) \[4, 5\]. The current evidence suggests that OS takes part in the mechanisms involved in initiation, promotion and progression of respiratory dise...

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Eligibility criteria

• Inclusion Criteria:
• • Malondialdehyde (MDA), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG), and coenzyme Q10 (CoQ10) levels were evaluated in the blood samples of patients with COPD, LC, and OSAS by high-pressure liquid chromatography method.
• Exclusion Criteria:
• • The diagnosis of lung cancer was based on the analysis of biopsy or cytologic specimens obtained by bronchoscopic examination, transthoracic biopsy or surgery. The patients Who hadn't have chemo or/and radiotherapy were included to the study.
• • The exclusion criteria for COPD, OSAS and lung cancer were the presence of the following: history of cardiovascular disease, hypertension, diabetes mellitus, inflammatory or infectious.