"Using Dilute Vinegar to Find Changes in Cells During Endoscopy for Patients With Barrett's Oesophagus" (The ABBA Study)
Launched by PORTSMOUTH HOSPITALS NHS TRUST · Mar 30, 2015
Trial Information
Current as of June 12, 2025
Completed
Keywords
ClinConnect Summary
This is a feasibility study to enable powering of a larger study. The investigators would assume a disease detection of 4.5% with acetic acid chromoendoscopy and 1.5% with protocol driven mapping biopsies. However, these assumptions are largely driven from a single centre cohort study and as such need clarification before they could be used for the purposes of powering a study. Based on the historical cohort studies and wide consultation within the British Society of Gastroenterology research committee and consultation with experts in the field, it is estimated that 200 patients would be re...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Aged 18 years or above
- • 2. Biopsy proven Barrett's metaplasia
- • 3. At least 2cm of Barrett's metaplasia (C0 M2)
- • 4. Willing and able to give informed consent
- Exclusion Criteria:
- • 1. Less than 2cm (C0 M2) of Barrett's metaplasia
- • 2. Significant oesophagitis
- • 3. Known or prior oesophageal cancer
- • 4. Known or prior oesophageal dysplasia (indefinite for dysplasia CAN be included)
- • 5. Previous endoscopic therapy
- • 6. Known allergy to acetic acid
- • 7. Previous inclusion in the study
About Portsmouth Hospitals Nhs Trust
Portsmouth Hospitals NHS Trust is a renowned healthcare institution dedicated to delivering high-quality medical services and advancing clinical research. Located in Portsmouth, the Trust encompasses a range of hospitals and specialized units, focusing on patient-centered care and innovative treatment approaches. With a commitment to improving health outcomes, the Trust actively engages in clinical trials that contribute to the development of new therapies and the enhancement of existing medical practices. By fostering collaboration among healthcare professionals, researchers, and patients, Portsmouth Hospitals NHS Trust plays a vital role in the advancement of medical knowledge and the improvement of healthcare delivery.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Portsmouth, , United Kingdom
Patients applied
Trial Officials
Pradeep Bhandari, MBBS, MD
Principal Investigator
Portsmouth Hospitals NHS Trust
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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