Alberta Lung Cancer Screening Program

Launched by UNIVERSITY OF CALGARY · Apr 30, 2015

Keywords

ClinConnect Summary

Lung cancer is the leading cause of cancer death in North America and in the world. The vast majority of lung cancers are associated with cigarette smoking. Lung cancer incidence and mortality rates are similar because lung cancer is a highly fatal disease. Unfortunately, the majority of lung cancers are detected at an advanced stage when they have a very poor prognosis. A substantial amount of data has been reported on low-dose computed tomography (LDCT) screening. The results of the National Lung Screening Trial (NLST) showed a 20% reduction in mortality from lung cancer with LDCT screeni...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subjects between the ages of 55 and 80 with a risk prediction model (RPM) ≥1.5% (≥ 1.5% risk of lung cancer over 6 years) OR NLST criteria (age 55-74; ≥ 30 pack-year smoking history; ongoing smoking or quit within 15 years).
• • Ability to provide informed consent and participate in study procedures.
• Exclusion Criteria:
• • Any medical condition, such as severe heart disease (e.g. unstable angina, chronic congestive heart failure), severe lung disease or lung disease requiring supplemental oxygen that in the opinion of the physician unlikely to benefit from screening due to shortened life-expectancy from the co-morbidities or inability to tolerate diagnosis and treatment of a screen detected abnormality. European Cooperative Oncology Group performance status \> 2.
• • History of lung cancer.
• • Have had other cancer or treatment for cancer within the past 5 years with the exception of the following cancers: non-melanomatous skin cancer, localized prostate cancer, carcinoma in situ (CIS) of the cervix, or superficial bladder cancer. Treatment of the exceptions must have ended \> 6 months before registration into this study.
• • Pregnancy.
• • Hemoptysis in past 12 months.
• • Unexplained weight loss \>15 pounds / 7kg in past 12 months.
• • Unwilling to have a LDCT of chest.
• • Unwilling to sign a consent.
• • Have had a CT scan of the chest in the last 2 years.